ATOH1

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Atonal homolog 1 (Drosophila)
Identifiers
Symbol(s) ATOH1; ATH1; HATH1; MATH-1
External IDs OMIM: 601461 MGI104654 HomoloGene31297
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 474 11921
Ensembl ENSG00000172238 ENSMUSG00000073043
Uniprot Q92858 P48985
Refseq NM_005172 (mRNA)
NP_005163 (protein)
NM_007500 (mRNA)
NP_031526 (protein)
Location Chr 4: 94.97 - 94.97 Mb Chr 6: 64.66 - 64.66 Mb
Pubmed search [1] [2]

Atonal homolog 1 (Drosophila), also known as ATOH1, is a human gene.[1]

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.[1]

[edit] References

[edit] Further reading

  • Leow CC, Polakis P, Gao WQ (2006). "A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma.". Ann. N. Y. Acad. Sci. 1059: 174–83. doi:10.1196/annals.1339.048. PMID 16382053. 
  • Ben-Arie N, McCall AE, Berkman S, et al. (1997). "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis.". Hum. Mol. Genet. 5 (9): 1207–16. PMID 8872459. 
  • Helms AW, Johnson JE (1998). "Progenitors of dorsal commissural interneurons are defined by MATH1 expression.". Development 125 (5): 919–28. PMID 9449674. 
  • Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221. 
  • Brown NL, Dagenais SL, Chen CM, Glaser T (2002). "Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development.". Mamm. Genome 13 (2): 95–101. doi:10.1007/s00335-001-2101-3. PMID 11889557. 
  • Leonard JH, Cook AL, Van Gele M, et al. (2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.". Int. J. Cancer 101 (2): 103–10. doi:10.1002/ijc.10554. PMID 12209986. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gazit R, Krizhanovsky V, Ben-Arie N (2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.". Development 131 (4): 903–13. doi:10.1242/dev.00982. PMID 14757642. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Sekine A, Akiyama Y, Yanagihara K, Yuasa Y (2006). "Hath1 up-regulates gastric mucin gene expression in gastric cells.". Biochem. Biophys. Res. Commun. 344 (4): 1166–71. doi:10.1016/j.bbrc.2006.03.238. PMID 16647036. 
  • Mutoh H, Sakamoto H, Hayakawa H, et al. (2006). "The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1.". Differentiation 74 (6): 313–21. doi:10.1111/j.1432-0436.2006.00074.x. PMID 16831200. 
  • Park ET, Oh HK, Gum JR, et al. (2006). "HATH1 expression in mucinous cancers of the colorectum and related lesions.". Clin. Cancer Res. 12 (18): 5403–10. doi:10.1158/1078-0432.CCR-06-0573. PMID 17000673. 
  • Tsuchiya K, Nakamura T, Okamoto R, et al. (2007). "Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.". Gastroenterology 132 (1): 208–20. doi:10.1053/j.gastro.2006.10.031. PMID 17241872. 
  • Du X, Jensen P, Goldowitz D, Hamre KM (2007). "Wild-type cells rescue genotypically Math1-null hair cells in the inner ears of chimeric mice.". Dev. Biol. 305 (2): 430–8. doi:10.1016/j.ydbio.2007.02.028. PMID 17397818. 
  • Westerman BA, Breuer RH, Poutsma A, et al. (2007). "Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors.". Int. J. Biol. Markers 22 (2): 114–23. PMID 17549667. 
  • Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells.". FEBS Lett. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772. 

[edit] External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.