ATG5

From Wikipedia, the free encyclopedia

ATG5 autophagy related 5 homolog (S. cerevisiae)

Identifiers

ATG5; ASP; APG5; APG5L; hAPG5

External IDs

OMIM: 604261 MGI: 1277186 HomoloGene: 3566

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cytoplasm • autophagic vacuole
Biological Process:	• autophagic vacuole formation • autophagy • apoptosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004849 (mRNA)
NP_004840 (protein)

NM_053069 (mRNA)
NP_444299 (protein)

Location

Chr 6: 106.74 - 106.88 Mb

Chr 10: 43.96 - 44.05 Mb

Pubmed search

[1]

[2]

ATG5 autophagy related 5 homolog (S. cerevisiae), also known as ATG5, is a human gene.^[1]

[edit] References

^ Entrez Gene: ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae).

[edit] Further reading

Grand RJ, Milner AE, Mustoe T, et al. (1995). "A novel protein expressed in mammalian cells undergoing apoptosis.". Exp. Cell Res. 218 (2): 439–51. doi:10.1006/excr.1995.1177. PMID 7796880.
Hammond EM, Brunet CL, Johnson GD, et al. (1998). "Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast.". FEBS Lett. 425 (3): 391–5. PMID 9563500.
Mizushima N, Sugita H, Yoshimori T, Ohsumi Y (1999). "A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy.". J. Biol. Chem. 273 (51): 33889–92. PMID 9852036.
Schmeiser K, Armstrong S, Hammond EM, Grand RJ (2000). "Assignment of the yeast APG5 human homologue APG5L to chromosome band 6q21 by fluorescence in situ hybridisation.". Cytogenet. Cell Genet. 87 (3-4): 213–4. PMID 10702672.
Mizushima N, Yamamoto A, Hatano M, et al. (2001). "Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells.". J. Cell Biol. 152 (4): 657–68. PMID 11266458.
Baumann P, Cech TR (2001). "Pot1, the putative telomere end-binding protein in fission yeast and humans.". Science 292 (5519): 1171–5. doi:10.1126/science.1060036. PMID 11349150.
Chen Y, Peng XZ, Piao YJ (2001). "[Bioinformatics analysis of autophagy 5 gene structure]". Yi Chuan Xue Bao 28 (11): 1077–84. PMID 11725643.
Tanida I, Tanida-Miyake E, Komatsu M, et al. (2002). "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.". J. Biol. Chem. 277 (16): 13739–44. doi:10.1074/jbc.M200385200. PMID 11825910.
Tanida I, Nishitani T, Nemoto T, et al. (2002). "Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing.". Biochem. Biophys. Res. Commun. 296 (5): 1164–70. PMID 12207896.
Yung HW, Xue L, Tolkovsky AM (2002). "Apoptosis-specific protein (ASP 45 kDa) is distinct from human Apg5, the homologue of the yeast autophagic gene apg5.". FEBS Lett. 531 (2): 168–72. PMID 12417306.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mizushima N, Yoshimori T, Ohsumi Y (2003). "Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method.". FEBS Lett. 532 (3): 450–4. PMID 12482611.
Mizushima N, Kuma A, Kobayashi Y, et al. (2004). "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate.". J. Cell. Sci. 116 (Pt 9): 1679–88. PMID 12665549.
Li Z, Hu CY, Mo BQ, et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng 22 (4): 380–4. PMID 12703993.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Simonsen A, Birkeland HC, Gillooly DJ, et al. (2005). "Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.". J. Cell. Sci. 117 (Pt 18): 4239–51. doi:10.1242/jcs.01287. PMID 15292400.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Pyo JO, Jang MH, Kwon YK, et al. (2005). "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death.". J. Biol. Chem. 280 (21): 20722–9. doi:10.1074/jbc.M413934200. PMID 15778222.