ATG4B

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ATG4 autophagy related 4 homolog B (S. cerevisiae)
PDB rendering based on 2cy7.
Available structures: 2cy7, 2d1i, 2z0d, 2z0e
Identifiers
Symbol(s) ATG4B; APG4B; AUTL1; MGC1353
External IDs HomoloGene: 88819
Orthologs
Human Mouse
Entrez 23192 n/a


Refseq NM_013325 (mRNA)
NP_037457 (protein)		 n/a (mRNA)
n/a (protein)
Pubmed search [1] n/a

ATG4 autophagy related 4 homolog B (S. cerevisiae), also known as ATG4B, is a human gene.[1]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]

[edit] References

  1. ^ a b Entrez Gene: ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae).

[edit] Further reading

  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Mariño G, Uría JA, Puente XS, et al. (2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.". J. Biol. Chem. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Kabeya Y, Mizushima N, Yamamoto A, et al. (2005). "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.". J. Cell. Sci. 117 (Pt 13): 2805–12. doi:10.1242/jcs.01131. PMID 15169837. 
  • Tanida I, Sou YS, Ezaki J, et al. (2004). "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.". J. Biol. Chem. 279 (35): 36268–76. doi:10.1074/jbc.M401461200. PMID 15187094. 
  • Tanida I, Ueno T, Kominami E (2005). "Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes.". J. Biol. Chem. 279 (46): 47704–10. doi:10.1074/jbc.M407016200. PMID 15355958. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Sugawara K, Suzuki NN, Fujioka Y, et al. (2006). "Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy.". J. Biol. Chem. 280 (48): 40058–65. doi:10.1074/jbc.M509158200. PMID 16183633. 
  • Kumanomidou T, Mizushima T, Komatsu M, et al. (2006). "The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers.". J. Mol. Biol. 355 (4): 612–8. doi:10.1016/j.jmb.2005.11.018. PMID 16325851. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
  • Tanida I, Sou YS, Minematsu-Ikeguchi N, et al. (2006). "Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3.". FEBS J. 273 (11): 2553–62. doi:10.1111/j.1742-4658.2006.05260.x. PMID 16704426. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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