ATG16L1

From Wikipedia, the free encyclopedia

ATG16 autophagy related 16-like 1 (S. cerevisiae)

Identifiers

ATG16L1; APG16L; ATG16L; FLJ00045; FLJ10035; FLJ10828; FLJ22677; WDR30

External IDs

OMIM: 610767 MGI: 1924290 HomoloGene: 41786

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• autophagic vacuole • membrane
Biological Process:	• autophagy • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_198890 (mRNA)
NP_942593 (protein)

NM_029846 (mRNA)
NP_084122 (protein)

Location

Chr 2: 233.83 - 233.87 Mb

Chr 1: 89.59 - 89.62 Mb

Pubmed search

[1]

[2]

ATG16 autophagy related 16-like 1 (S. cerevisiae), also known as ATG16L1, is a human gene.^[1]

[edit] References

^ Entrez Gene: ATG16L1 ATG16 autophagy related 16-like 1 (S. cerevisiae).

[edit] Further reading

Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mizushima N, Kuma A, Kobayashi Y, et al. (2004). "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate.". J. Cell. Sci. 116 (Pt 9): 1679–88. PMID 12665549.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zheng H, Ji C, Li J, et al. (2005). "Cloning and analysis of human Apg16L.". DNA Seq. 15 (4): 303–5. PMID 15620219.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Hampe J, Franke A, Rosenstiel P, et al. (2007). "A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.". Nat. Genet. 39 (2): 207–11. doi:10.1038/ng1954. PMID 17200669.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Prescott NJ, Fisher SA, Franke A, et al. (2007). "A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.". Gastroenterology 132 (5): 1665–71. doi:10.1053/j.gastro.2007.03.034. PMID 17484864.
Yamazaki K, Onouchi Y, Takazoe M, et al. (2007). "Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients.". J. Hum. Genet. 52 (7): 575–83. doi:10.1007/s10038-007-0156-z. PMID 17534574.
Baldassano RN, Bradfield JP, Monos DS, et al. (2007). "Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease.". Gut 56 (8): 1171–3. doi:10.1136/gut.2007.122747. PMID 17625155.