ASXL1

From Wikipedia, the free encyclopedia

Additional sex combs like 1 (Drosophila)

Identifiers

ASXL1; KIAA0978; MGC117280; MGC71111

External IDs

Gene ontology
Molecular Function:	• zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015338 (mRNA)
NP_056153 (protein)

XM_001004872 (mRNA)
XP_001004872 (protein)

Location

Chr 20: 30.41 - 30.49 Mb

Chr 2: 153.04 - 153.09 Mb

Pubmed search

[1]

[2]

Additional sex combs like 1 (Drosophila), also known as ASXL1, is a human gene.^[1]

In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. Although the function of the protein encoded by this gene is not known, it does show some sequence similarity to the protein encoded by the Drosophila Asx gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ASXL1 additional sex combs like 1 (Drosophila).

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Sinclair DA, Campbell RB, Nicholls F, et al. (1992). "Genetic analysis of the additional sex combs locus of Drosophila melanogaster.". Genetics 130 (4): 817–25. PMID 1349871.
Sinclair DA, Milne TA, Hodgson JW, et al. (1998). "The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.". Development 125 (7): 1207–16. PMID 9477319.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fisher CL, Berger J, Randazzo F, Brock HW (2003). "A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11.". Gene 306: 115–26. PMID 12657473.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.