Asporin

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Asporin
Identifiers
Symbol(s) ASPN; FLJ20129; PLAP1; SLRR1C
External IDs OMIM: 608135 MGI: 1913945 HomoloGene: 32357
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 54829 66695
Ensembl ENSG00000106819 ENSMUSG00000021388
Uniprot Q9BXN1 Q9CTL6
Refseq NM_017680 (mRNA)
NP_060150 (protein)		 NM_025711 (mRNA)
NP_079987 (protein)
Location Chr 9: 94.26 - 94.28 Mb Chr 13: 49.56 - 49.58 Mb
Pubmed search [1] [2]

Asporin, also known as ASPN, is a human gene.[1]

ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: ASPN asporin.

[edit] Further reading

  • Lorenzo P, Aspberg A, Onnerfjord P, et al. (2001). "Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan.". J. Biol. Chem. 276 (15): 12201–11. doi:10.1074/jbc.M010932200. PMID 11152692. 
  • Henry SP, Takanosu M, Boyd TC, et al. (2001). "Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family.". J. Biol. Chem. 276 (15): 12212–21. doi:10.1074/jbc.M011290200. PMID 11152695. 
  • Yamada S, Murakami S, Matoba R, et al. (2001). "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene.". Gene 275 (2): 279–86. PMID 11587855. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Kizawa H, Kou I, Iida A, et al. (2005). "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.". Nat. Genet. 37 (2): 138–44. doi:10.1038/ng1496. PMID 15640800. 
  • Rodriguez-Lopez J, Pombo-Suarez M, Liz M, et al. (2006). "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians.". Arthritis Res. Ther. 8 (3): R55. doi:10.1186/ar1920. PMID 16542493. 
  • Yamada S, Ozawa Y, Tomoeda M, et al. (2006). "Regulation of PLAP-1 expression in periodontal ligament cells.". J. Dent. Res. 85 (5): 447–51. PMID 16632759. 
  • Jiang Q, Shi D, Yi L, et al. (2007). "Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese.". J. Hum. Genet. 51 (12): 1068–72. doi:10.1007/s10038-006-0065-6. PMID 17024313. 
  • Nakamura T, Shi D, Tzetis M, et al. (2007). "Meta-analysis of association between the ASPN D-repeat and osteoarthritis.". Hum. Mol. Genet. 16 (14): 1676–81. doi:10.1093/hmg/ddm115. PMID 17517696. 
  • Shi D, Nakamura T, Dai J, et al. (2007). "Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population.". J. Hum. Genet. 52 (8): 664–7. doi:10.1007/s10038-007-0166-x. PMID 17603749. 
  • Kou I, Nakajima M, Ikegawa S (2007). "Expression and regulation of the osteoarthritis-associated protein asporin.". J. Biol. Chem. 282 (44): 32193–9. doi:10.1074/jbc.M706262200. PMID 17804408. 
  • Nakajima M, Kizawa H, Saitoh M, et al. (2007). "Mechanisms for asporin function and regulation in articular cartilage.". J. Biol. Chem. 282 (44): 32185–92. doi:10.1074/jbc.M700522200. PMID 17827158. 
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