Aspergillus fumigatus

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Aspergillus fumigatus
Aspergillus fumigatus
Aspergillus fumigatus
Scientific classification
Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Trichocomaceae
Genus: Aspergillus
Species: A. fumigatus
Binomial name
Aspergillus fumigatus
Fresenius 1863

Aspergillus fumigatus is a fungus of the genus Aspergillus, and is one of the most common Aspergillus species to cause disease in immunocompromised individuals.

A. fumigatus has a stable haploid genome, with no known sexual cycle, and reproduces by forming conidiospores that are released into the environment. Capable of growth at 37°C (human body temperature), spores are common inhalation pollutants; typically, however, these are quickly eliminated by the immune system in healthy individuals.

When the fermentation broth of A. fumigatus was screened, a number of indolic alkaloids with anti-mitotic properties were discovered.[1] The compounds of interest have been of a class known as tryprostatins, with spirotryprostatin B being of special interest as an anti-cancer drug.

[edit] Genome

The genome sequences of three Aspergillus species—Aspergillus fumigatus, Aspergillus nidulans, and Aspergillus oryzae—were published in the journal Nature in December 2005.[2][3][4]

[edit] Gallery

[edit] See also

[edit] References

  1. ^ Cui CB et al (1996). "Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus". J. Antibiot. 49: 832-835. PMID 8823522. 
  2. ^ Galagan JE et al (2005). "Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae". Nature 438 (7071): 1105-15. doi:10.1038/nature04341. PMID 16372000. 
  3. ^ Nierman WC et al (2005). "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus". Nature 438 (7071): 1151-6. doi:10.1038/nature04332. PMID 16372009. 
  4. ^ Machida M et al (2005). "Genome sequencing and analysis of Aspergillus oryzae". Nature 438 (7071): 1157-61. doi:10.1038/nature04300. PMID 16372010. 

[edit] External links

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