Aspartate-ammonia ligase (ADP-forming)

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In enzymology, an aspartate-ammonia ligase (ADP-forming) (EC 6.3.1.4) is an enzyme that catalyzes the chemical reaction

ATP + L-aspartate + NH₃ ADP + phosphate + L-asparagine

The 3 substrates of this enzyme are ATP, L-aspartate, and NH₃, whereas its 3 products are ADP, phosphate, and L-asparagine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (ADP-forming). Other names in common use include asparagine synthetase (ADP-forming), and asparagine synthetase (adenosine diphosphate-forming). This enzyme participates in nitrogen metabolism.

[edit] References

• IUBMB entry for 6.3.1.4
• BRENDA references for 6.3.1.4 (Recommended.)
• PubMed references for 6.3.1.4
• PubMed Central references for 6.3.1.4
• Google Scholar references for 6.3.1.4
• Nair PM (1969). "Asparagine synthetase from gamma-irradiated potatoes". Arch. Biochem. Biophys. 133: 208–15. doi:10.1016/0003-9861(69)90447-0. PMID 5820987. 

[edit] External links

The CAS registry number for this enzyme class is 37318-61-9.

• IUBMB entry for 6.3.1.4

• KEGG entry for 6.3.1.4

• BRENDA entry for 6.3.1.4

• NiceZyme view of 6.3.1.4

• EC2PDB: PDB structures for 6.3.1.4

• PRIAM entry for 6.3.1.4

• PUMA2 entry for 6.3.1.4

• IntEnz: Integrated Enzyme entry for 6.3.1.4

• MetaCyc entry for 6.3.1.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047478: aspartate-ammonia ligase (ADP-forming)

• AMIGO entry for GO code 0047478: aspartate-ammonia ligase (ADP-forming)