Asparagine-tRNA ligase
From Wikipedia, the free encyclopedia
In enzymology, an asparagine-tRNA ligase (EC 6.1.1.22) is an enzyme that catalyzes the chemical reaction
- ATP + L-asparagine + tRNAAsn
AMP + diphosphate + L-asparaginyl-tRNAAsn
The 3 substrates of this enzyme are ATP, L-asparagine, and tRNA(Asn), whereas its 3 products are AMP, diphosphate, and L-asparaginyl-tRNA(Asn).
This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-asparagine:tRNAAsn ligase (AMP-forming). Other names in common use include asparaginyl-tRNA synthetase, asparaginyl-transfer ribonucleate synthetase, asparaginyl transfer RNA synthetase, asparaginyl transfer ribonucleic acid synthetase, asparagyl-transfer RNA synthetase, and asparagine translase. This enzyme participates in alanine and aspartate metabolism and aminoacyl-trna biosynthesis.
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[edit] Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1X54, 1X55, and 1X56.
[edit] References
- IUBMB entry for 6.1.1.22
- BRENDA references for 6.1.1.22 (Recommended.)
- PubMed references for 6.1.1.22
- PubMed Central references for 6.1.1.22
- Google Scholar references for 6.1.1.22
- Davies MR, Marshall RD (1972). "Partial purification of L-asparaginyl-tRNA synthetase from rabbit liver". Biochem. Biophys. Res. Commun. 47: 1386–95. doi:. PMID 5040239.
[edit] External links
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- The CAS registry number for this enzyme class is 37211-76-0.
[edit] Gene Ontology (GO) codes
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