ASNA1

From Wikipedia, the free encyclopedia

ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

Identifiers

ASNA1; ARSA-I; ARSA1; MGC3821

External IDs

OMIM: 601913 MGI: 1928379 HomoloGene: 31513

Gene ontology
Molecular Function:	• nucleotide binding • transporter activity • ATP binding • arsenite transmembrane transporter activity • arsenite transmembrane-transporting ATPase activity • hydrolase activity
Cellular Component:	• soluble fraction • nucleolus • cytoplasm • membrane
Biological Process:	• transport • anion transport • response to arsenic

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004317 (mRNA)
NP_004308 (protein)

NM_019652 (mRNA)
NP_062626 (protein)

Location

Chr 19: 12.71 - 12.72 Mb

Chr 8: 87.91 - 87.92 Mb

Pubmed search

[1]

[2]

ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial), also known as ASNA1, is a human gene.^[1]

ASNA1 is the human homolog of the bacterial arsA gene. In E. coli, ArsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Kurdi-Haidar B, Aebi S, Heath D, et al. (1997). "Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter.". Genomics 36 (3): 486–91. doi:10.1006/geno.1996.0494. PMID 8884272.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kurdi-Haidar B, Heath D, Aebi S, Howell SB (1998). "Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I).". J. Biol. Chem. 273 (35): 22173–6. PMID 9712828.
Kurdi-Haidar B, Hom DK, Flittner DE, et al. (1998). "Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I).". J. Cell. Biochem. 71 (1): 1–10. PMID 9736449.
Kurdi-Haidar B, Heath D, Lennon G, Howell SB (2000). "Chromosomal localization and genomic structure of the human arsenite-stimulated ATPase (hASNA-I).". Somat. Cell Mol. Genet. 24 (5): 307–11. PMID 10696239.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kao G, Nordenson C, Still M, et al. (2007). "ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.". Cell 128 (3): 577–87. doi:10.1016/j.cell.2006.12.031. PMID 17289575.
Stefanovic S, Hegde RS (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER.". Cell 128 (6): 1147–59. doi:10.1016/j.cell.2007.01.036. PMID 17382883.