Asinger reaction

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The Asinger-reaction was invented in 1958 by Friedrich Asinger. An α-halogenated carbonyl-component reacts with sodium-hydrogensulfide NaSH and forms in situ a Thiole. The thiole reacts directly with another carbonyl-component and ammonia to form Thiazolines.

image:Asinger Reaktion.png

The reaction works also by using sulphur, an in α–position substitutable ketone, a further carbonyl-component and ammonia under formation of mixtures.

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