Ashepoo River

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Ashepoo River is a short blackwater river in South Carolina. It rises in a confluence of swamps south of Walterboro, flows in southeast direction and then empties into Saint Helena Sound at 32.49° N 80.42389° W. The entire course of the river lies within the boundaries of Colleton County. The Ashepoo basin forms part of the 11,815 acre (48 km²) ACE Basin National Wildlife Refuge, a coastal learning center that encompasses its bottomlands confluence with the Combahee and Edisto river basins (thus, the origin of the refuge's name, formed from the first letters of the names of the 3 rivers: A-C-E). Many people enjoy fishing and boating on thtis river and others in South Carolina.

The name comes from the Ashepoo subtribe of the Cusabo Indians.