ASH1L

From Wikipedia, the free encyclopedia

Ash1 (absent, small, or homeotic)-like (Drosophila)

Identifiers

ASH1L; ASH1; FLJ10504; ASH1L1; KIAA1420

External IDs

OMIM: 607999 MGI: 2183158 HomoloGene: 10225

Gene ontology
Molecular Function:	• DNA binding • RNA polymerase II transcription factor activity • protein binding • methyltransferase activity • zinc ion binding • transferase activity • histone-lysine N-methyltransferase activity • metal ion binding
Cellular Component:	• nucleus • tight junction
Biological Process:	• DNA packaging • transcription • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • cell-cell signaling • chromatin modification

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018489 (mRNA)
NP_060959 (protein)

NM_138679 (mRNA)
NP_619620 (protein)

Location

Chr 1: 153.57 - 153.8 Mb

Chr 3: 89.05 - 89.17 Mb

Pubmed search

[1]

[2]

Ash1 (absent, small, or homeotic)-like (Drosophila), also known as ASH1L, is a human gene.^[1]

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.^[1]

[edit] References

^ ^a ^b Entrez Gene: ASH1L ash1 (absent, small, or homeotic)-like (Drosophila).

[edit] Further reading

Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (1): 65-73. PMID 10718198.
Nakamura T, Blechman J, Tada S, et al. (2000). "huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions.". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7284-9. PMID 10860993.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Kuryshev VY, Vorobyov E, Zink D, et al. (2006). "An anthropoid-specific segmental duplication on human chromosome 1q22.". Genomics 88 (2): 143-51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells.". J. Proteome Res. 6 (1): 298-305. doi:10.1021/pr060438j. PMID 17203973.
Gregory GD, Vakoc CR, Rozovskaia T, et al. (2007). "Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes.". Mol. Cell. Biol. 27 (24): 8466-79. doi:10.1128/MCB.00993-07. PMID 17923682.