Ascorbate 2,3-dioxygenase

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In enzymology, an ascorbate 2,3-dioxygenase (EC 1.13.11.13) is an enzyme that catalyzes the chemical reaction

ascorbate + O₂ + H₂O oxalate + threonate

The 3 substrates of this enzyme are ascorbate, O₂, and H₂O, whereas its two products are oxalate and threonate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O₂. The systematic name of this enzyme class is ascorbate:oxygen 2,3-oxidoreductase (bond-cleaving). This enzyme is also called AAoxygenase. This enzyme participates in ascorbate and aldarate metabolism. It employs one cofactor, iron.

[edit] References

• IUBMB entry for 1.13.11.13
• BRENDA references for 1.13.11.13 (Recommended.)
• PubMed references for 1.13.11.13
• PubMed Central references for 1.13.11.13
• Google Scholar references for 1.13.11.13
• White GA, Krupka RM (1965). "Ascorbic acid oxidase and ascorbic acid oxygenase of Myrothecium verrucaria". Arch. Biochem. Biophys. 110: 448–61. doi:10.1016/0003-9861(65)90436-4. PMID 5891457. 

[edit] External links

The CAS registry number for this enzyme class is 37256-55-6.

• IUBMB entry for 1.13.11.13

• KEGG entry for 1.13.11.13

• BRENDA entry for 1.13.11.13

• NiceZyme view of 1.13.11.13

• EC2PDB: PDB structures for 1.13.11.13

• PRIAM entry for 1.13.11.13

• PUMA2 entry for 1.13.11.13

• IntEnz: Integrated Enzyme entry for 1.13.11.13

• MetaCyc entry for 1.13.11.13

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047687: ascorbate 2,3-dioxygenase

• AMIGO entry for GO code 0047687: ascorbate 2,3-dioxygenase