ASB6

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Ankyrin repeat and SOCS box-containing 6
Identifiers
Symbol(s) ASB6; FLJ20548; MGC1024
External IDs MGI: 1919573 HomoloGene: 9895
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 140459 72323
Ensembl ENSG00000148331 ENSMUSG00000039483
Uniprot Q9NWX5 Q6BCN6
Refseq NM_017873 (mRNA)
NP_060343 (protein)		 NM_133346 (mRNA)
NP_579924 (protein)
Location Chr 9: 131.44 - 131.44 Mb Chr 2: 30.65 - 30.65 Mb
Pubmed search [1] [2]

Ankyrin repeat and SOCS box-containing 6, also known as ASB6, is a human gene.[1]

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.[1]

[edit] References

  1. ^ a b Entrez Gene: ASB6 ankyrin repeat and SOCS box-containing 6.

[edit] Further reading

  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235-41. PMID 12076535. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wilcox A, Katsanakis KD, Bheda F, Pillay TS (2004). "Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.". J. Biol. Chem. 279 (37): 38881-8. doi:10.1074/jbc.M406101200. PMID 15231829. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
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