ASB13

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Ankyrin repeat and SOCS box-containing 13
Identifiers
Symbol(s) ASB13; FLJ13134; MGC19879
External IDs MGI: 2145525 HomoloGene: 11666
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 79754 142688
Ensembl ENSG00000196372 ENSMUSG00000033781
Uniprot Q8WXK3 Q8VBX0
Refseq NM_024701 (mRNA)
NP_078977 (protein)		 NM_080857 (mRNA)
NP_543133 (protein)
Location Chr 10: 5.72 - 5.75 Mb Chr 13: 3.63 - 3.65 Mb
Pubmed search [1] [2]

Ankyrin repeat and SOCS box-containing 13, also known as ASB13, is a human gene.[1]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length sequences are not known.[1]

[edit] References

  1. ^ a b Entrez Gene: ASB13 ankyrin repeat and SOCS box-containing 13.

[edit] Further reading

  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235-41. PMID 12076535. 
  • Kohroki J, Nishiyama T, Nakamura T, Masuho Y (2006). "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes.". FEBS Lett. 579 (30): 6796-802. doi:10.1016/j.febslet.2005.11.016. PMID 16325183. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957-68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
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