AS3MT

From Wikipedia, the free encyclopedia

Arsenic (+3 oxidation state) methyltransferase

Identifiers

External IDs

MGI: 1929882 HomoloGene: 10754

Gene ontology
Molecular Function:	• methyltransferase activity • transferase activity • arsenite methyltransferase activity • methylarsonite methyltransferase activity
Cellular Component:	• cytosol
Biological Process:	• toxin metabolic process • arsonoacetate metabolic process

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_020682 (mRNA)
NP_065733 (protein)

NM_020577 (mRNA)
NP_065602 (protein)

Location

n/a

Chr 19: 46.76 - 46.79 Mb

Pubmed search

[1]

[2]

Arsenic (+3 oxidation state) methyltransferase, also known as AS3MT, is a human gene.^[1]

[edit] References

^ Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase.

[edit] Further reading

Hernández A, Xamena N, Sekaran C, et al.. "High arsenic metabolic efficiency in AS3MT287Thr allele carriers.". Pharmacogenet. Genomics 18 (4): 349-55. doi:10.1097/FPC.0b013e3282f7f46b. PMID 18334919.
Fujihara J, Kunito T, Agusa T, et al. (2008). "Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method.". Toxicol. Appl. Pharmacol. 225 (3): 251-4. doi:10.1016/j.taap.2007.08.010. PMID 17889916.
Hernández A, Xamena N, Surrallés J, et al. (2008). "Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile.". Mutat. Res. 637 (1-2): 80-92. doi:10.1016/j.mrfmmm.2007.07.004. PMID 17850829.
Lindberg AL, Kumar R, Goessler W, et al. (2007). "Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms.". Environ. Health Perspect. 115 (7): 1081-6. doi:10.1289/ehp.10026. PMID 17637926.
Schläwicke Engström K, Broberg K, Concha G, et al. (2007). "Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina.". Environ. Health Perspect. 115 (4): 599-605. doi:10.1289/ehp.9734. PMID 17450230.
Meza M, Gandolfi AJ, Klimecki WT (2007). "Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?". Toxicol. Appl. Pharmacol. 222 (3): 381-7. doi:10.1016/j.taap.2006.12.018. PMID 17306849.
Wood TC, Salavagionne OE, Mukherjee B, et al. (2006). "Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies.". J. Biol. Chem. 281 (11): 7364-73. doi:10.1074/jbc.M512227200. PMID 16407288.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Meza MM, Yu L, Rodriguez YY, et al. (2005). "Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children.". Environ. Health Perspect. 113 (6): 775-81. PMID 15929903.
Li J, Waters SB, Drobna Z, et al. (2005). "Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype.". Toxicol. Appl. Pharmacol. 204 (2): 164-9. doi:10.1016/j.taap.2004.12.002. PMID 15808521.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lin S, Shi Q, Nix FB, et al. (2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol.". J. Biol. Chem. 277 (13): 10795-803. doi:10.1074/jbc.M110246200. PMID 11790780.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.