Arylformamidase
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In enzymology, an arylformamidase (EC 3.5.1.9) is an enzyme that catalyzes the chemical reaction
- N-formyl-L-kynurenine + H2O
formate + L-kynurenine
Thus, the two substrates of this enzyme are N-formyl-L-kynurenine and H2O, whereas its two products are formate and L-kynurenine.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is aryl-formylamine amidohydrolase. Other names in common use include kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, formamidase I, and formamidase II. This enzyme participates in tryptophan metabolism and glyoxylate and dicarboxylate metabolism.
[edit] References
- IUBMB entry for 3.5.1.9
- BRENDA references for 3.5.1.9 (Recommended.)
- PubMed references for 3.5.1.9
- PubMed Central references for 3.5.1.9
- Google Scholar references for 3.5.1.9
- HAYAISHI O, STANIER RY (1951). "The bacterial oxidation of tryptophan. III. Enzymatic activities of cell-free extracts from bacteria employing the aromatic pathway". J. Bacteriol. 62: 691–709. PMID 14907621.
- JAKOBY WB (1954). "Kynurenine formamidase from Neurospora". J. Biol. Chem. 207: 657–63. PMID 13163050.
- MEHLER AH, KNOX WE (1950). "The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine". J. Biol. Chem. 187: 431–8. PMID 14794728.
[edit] External links
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- The CAS registry number for this enzyme class is 156229-75-3.
[edit] Gene Ontology (GO) codes
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