Arylesterase

From Wikipedia, the free encyclopedia

In enzymology, an arylesterase (EC 3.1.1.2) is an enzyme that catalyzes the chemical reaction

a phenyl acetate + H₂O a phenol + acetate

Thus, the two substrates of this enzyme are phenyl acetate and H₂O, whereas its two products are phenol and acetate.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is aryl-ester hydrolase. Other names in common use include A-esterase, paraoxonase, and aromatic esterase. This enzyme participates in bisphenol a degradation.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1V04 and 1VA4.

[edit] References

• IUBMB entry for 3.1.1.2
• BRENDA references for 3.1.1.2 (Recommended.)
• PubMed references for 3.1.1.2
• PubMed Central references for 3.1.1.2
• Google Scholar references for 3.1.1.2
• ALDRIDGE WN (1953). "Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination". Biochem. J. 53: 110–7. PMID 13032041. 
• AUGUSTINSSON KB, OLSSON B (1959). "Esterases in the milk and blood plasma of swine. I. Substrate specificity and electrophoresis studies". Biochem. J. 71: 477–84. PMID 13638253. 
• Bosmann HB (1972). "Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate". Biochim. Biophys. Acta. 276: 180–91. PMID 5047702. 
• Kim DH, Yang YS, Jakoby WB (1990). "Nonserine esterases from rat liver cytosol". Protein. Expr. Purif. 1: 19–27. doi:10.1016/1046-5928(90)90040-6. PMID 2152179. 
• Mackness MI, Thompson HM, Hardy AR, Walker CH (1987). "Distinction between 'A'-esterases and arylesterases. Implications for esterase classification". Biochem. J. 245: 293–6. PMID 2822017. 
• UK, 1989. "7 [PMID:15835926]". Khersonsky O, Tawfik DS.: DS. 
• "" . 
• Biochemistry 44 (2005) 6371-82. "8 [PMID:15772423]". Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN.: BN. 
• "" . 
• J Lipid Res 46 (2005) 1239-47. "". 

[edit] External links

The CAS registry number for this enzyme class is 9032-73-9.

• IUBMB entry for 3.1.1.2

• KEGG entry for 3.1.1.2

• BRENDA entry for 3.1.1.2

• NiceZyme view of 3.1.1.2

• EC2PDB: PDB structures for 3.1.1.2

• PRIAM entry for 3.1.1.2

• PUMA2 entry for 3.1.1.2

• IntEnz: Integrated Enzyme entry for 3.1.1.2

• MetaCyc entry for 3.1.1.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004064: arylesterase

• AMIGO entry for GO code 0004064: arylesterase