Arylacetonitrilase

From Wikipedia, the free encyclopedia

In enzymology, an arylacetonitrilase (EC 3.5.5.5) is an enzyme that catalyzes the chemical reaction

4-chlorophenylacetonitrile + 2 H₂O 4-chlorophenylacetate + NH₃

Thus, the two substrates of this enzyme are 4-chlorophenylacetonitrile and H₂O, whereas its two products are 4-chlorophenylacetate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is arylacetonitrile aminohydrolase. This enzyme participates in cyanoamino acid metabolism.

[edit] References

• IUBMB entry for 3.5.5.5
• BRENDA references for 3.5.5.5 (Recommended.)
• PubMed references for 3.5.5.5
• PubMed Central references for 3.5.5.5
• Google Scholar references for 3.5.5.5
• Mauger J, Nagasawa T and Yamada H (1990). "Occurrence of a novel nitrilase, arylacetonitrilase, in Alcaligenes faecalis JM3". Arch. Microbiol. 155: 1–6. doi:10.1007/BF00291265. 
• Nagasawa T, Mauger J, Yamada H (1990). "A novel nitrilase, arylacetonitrilase, of Alcaligenes faecalis JM3 Purification and characterization". Eur. J. Biochem. 194: 765–72. doi:10.1111/j.1432-1033.1990.tb19467.x. PMID 2269298. 

[edit] External links

The CAS registry number for this enzyme class is 132053-06-6.

• IUBMB entry for 3.5.5.5

• KEGG entry for 3.5.5.5

• BRENDA entry for 3.5.5.5

• NiceZyme view of 3.5.5.5

• EC2PDB: PDB structures for 3.5.5.5

• PRIAM entry for 3.5.5.5

• PUMA2 entry for 3.5.5.5

• IntEnz: Integrated Enzyme entry for 3.5.5.5

• MetaCyc entry for 3.5.5.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047428: arylacetonitrilase

• AMIGO entry for GO code 0047428: arylacetonitrilase