Aryl-aldehyde dehydrogenase (NADP+)

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In enzymology, an aryl-aldehyde dehydrogenase (NADP+) (EC 1.2.1.30) is an enzyme that catalyzes the chemical reaction

an aromatic aldehyde + NADP⁺ + AMP + diphosphate + H₂O $\rightleftharpoons$ an aromatic acid + NADPH + H⁺ + ATP

The 5 substrates of this enzyme are aromatic aldehyde, NADP⁺, AMP, diphosphate, and H₂O, whereas its 4 products are aromatic acid, NADPH, H⁺, and ATP.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aryl-aldehyde:NADP+ oxidoreductase (ATP-forming). Other names in common use include aromatic acid reductase, and aryl-aldehyde dehydrogenase (NADP+).

[edit] References

IUBMB entry for 1.2.1.30
BRENDA references for 1.2.1.30 (Recommended.)
PubMed references for 1.2.1.30
PubMed Central references for 1.2.1.30
Google Scholar references for 1.2.1.30
Gross GG (1972). "Formation and reduction of intermediate acyladenylate by aryl-aldehyde. NADP oxidoreductase from Neurospora crassa". Eur. J. Biochem. 31: 585–92. doi:10.1111/j.1432-1033.1972.tb02569.x. PMID 4405494.
Gross GG, Zenk MH (1969). "[Reduction of aromatic acids to aldehydes and alcohols in the cell-free system. 1. Purification and properties of aryl-aldehyde: NADP-oxidoreductase from Neurospora crassa]". Eur. J. Biochem. 8: 413–9. PMID 4389863.