Aryl-aldehyde dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, an aryl-aldehyde dehydrogenase (EC 1.2.1.29) is an enzyme that catalyzes the chemical reaction

an aromatic aldehyde + NAD⁺ + H₂O an aromatic acid + NADH + H⁺

The 3 substrates of this enzyme are aromatic aldehyde, NAD⁺, and H₂O, whereas its 3 products are aromatic acid, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aryl-aldehyde:NAD+ oxidoreductase. This enzyme participates in tyrosine metabolism and biphenyl degradation.

[edit] References

• IUBMB entry for 1.2.1.29
• BRENDA references for 1.2.1.29 (Recommended.)
• PubMed references for 1.2.1.29
• PubMed Central references for 1.2.1.29
• Google Scholar references for 1.2.1.29
• Raison JK, Henson G, Rienits KG (1966). "The oxidation of gentisaldehyde by nicotinamide-adenine dinucleotide-specific, aromatic aldehyde dehydrogenase from rabbit liver". Biochim. Biophys. Acta. 118: 285–98. PMID 4289834. 

[edit] External links

The CAS registry number for this enzyme class is 37250-94-5.

• IUBMB entry for 1.2.1.29

• KEGG entry for 1.2.1.29

• BRENDA entry for 1.2.1.29

• NiceZyme view of 1.2.1.29

• EC2PDB: PDB structures for 1.2.1.29

• PRIAM entry for 1.2.1.29

• PUMA2 entry for 1.2.1.29

• IntEnz: Integrated Enzyme entry for 1.2.1.29

• MetaCyc entry for 1.2.1.29

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019108: aryl-aldehyde dehydrogenase

• AMIGO entry for GO code 0019108: aryl-aldehyde dehydrogenase