ART4
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ADP-ribosyltransferase 4 (Dombrock blood group)
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| Identifiers | ||||||||||||||
| Symbol(s) | ART4; CD297; DO; DOK1 | |||||||||||||
| External IDs | OMIM: 110600 MGI: 1202710 HomoloGene: 10883 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 420 | 109978 | ||||||||||||
| Ensembl | ENSG00000111339 | ENSMUSG00000030217 | ||||||||||||
| Uniprot | Q93070 | n/a | ||||||||||||
| Refseq | NM_021071 (mRNA) NP_066549 (protein) |
NM_026639 (mRNA) NP_080915 (protein) |
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| Location | Chr 12: 14.87 - 14.89 Mb | Chr 6: 136.81 - 136.82 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
ADP-ribosyltransferase 4 (Dombrock blood group), also known as ART4, is a human gene.[1] ART4 has also been designated as CD297 (cluster of differentiation 297).
This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.[1]
[edit] References
[edit] Further reading
- Reid ME (2003). "The Dombrock blood group system: a review.". Transfusion 43 (1): 107–14. PMID 12519438.
- Tippett P (1967). "Genetics of the Dombrock blood group system.". J. Med. Genet. 4 (1): 7–11. PMID 6034522.
- Eiberg H, Mohr J (1996). "Dombrock blood group (DO): assignment to chromosome 12p.". Hum. Genet. 98 (5): 518–21. PMID 8882867.
- Koch-Nolte F, Haag F, Braren R, et al. (1997). "Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins.". Genomics 39 (3): 370–6. doi:. PMID 9119374.
- Mauthe J, Coghlan G, Zelinski T (2000). "Confirmation of the assignment of the Dombrock blood group locus (DO) to chromosome 12p: narrowing the boundaries to 12p12.3-p13.2.". Vox Sang. 79 (1): 53–6. PMID 10971215.
- Gubin AN, Njoroge JM, Wojda U, et al. (2000). "Identification of the dombrock blood group glycoprotein as a polymorphic member of the ADP-ribosyltransferase gene family.". Blood 96 (7): 2621–7. PMID 11001920.
- Wu GG, Jin SZ, Deng ZH, Zhao TM (2002). "Polymerase chain reaction with sequence-specific primers-based genotyping of the human Dombrock blood group DO1 and DO2 alleles and the DO gene frequencies in Chinese blood donors.". Vox Sang. 81 (1): 49–51. PMID 11520417.
- Rios M, Hue-Roye K, Øyen R, et al. (2002). "Insights into the Holley- and Joseph- phenotypes.". Transfusion 42 (1): 52–8. PMID 11896313.
- Rios M, Storry JR, Hue-Roye K, et al. (2002). "Two new molecular bases for the Dombrock null phenotype.". Br. J. Haematol. 117 (3): 765–7. PMID 12028057.
- Glowacki G, Braren R, Firner K, et al. (2003). "The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.". Protein Sci. 11 (7): 1657–70. PMID 12070318.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:. PMID 15489334.
- Grahnert A, Friedrich M, Engeland K, Hauschildt S (2005). "Analysis of mono-ADP-ribosyltransferase 4 gene expression in human monocytes: splicing pattern and potential regulatory elements.". Biochim. Biophys. Acta 1730 (3): 173–86. doi:. PMID 16140404.
[edit] External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
