ARPC4

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Actin related protein 2/3 complex, subunit 4, 20kDa
PDB rendering based on 1k8k.
Available structures: 1k8k, 1tyq, 1u2v, 2p9i, 2p9k, 2p9l, 2p9n, 2p9p, 2p9s, 2p9u
Identifiers
Symbol(s) ARPC4; ARC20; MGC13544; p20-Arc
External IDs OMIM: 604226 MGI: 1915339 HomoloGene: 4177
Orthologs
Human Mouse
Entrez 10093 68089


Refseq NM_001024959 (mRNA)
NP_001020130 (protein)		 NM_026552 (mRNA)
NP_080828 (protein)
Pubmed search [1] [2]

Actin related protein 2/3 complex, subunit 4, 20kDa, also known as ARPC4, is a human gene.[1]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p20 subunit, has yet to be determined. Three transcript variants encoding two distinct isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa.

[edit] Further reading

  • Welch MD, Iwamatsu A, Mitchison TJ (1997). "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes.". Nature 385 (6613): 265–9. doi:10.1038/385265a0. PMID 9000076. 
  • Welch MD, DePace AH, Verma S, et al. (1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.". J. Cell Biol. 138 (2): 375–84. PMID 9230079. 
  • Machesky LM, Reeves E, Wientjes F, et al. (1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.". Biochem. J. 328 ( Pt 1): 105–12. PMID 9359840. 
  • Zhao X, Yang Z, Qian M, Zhu X (2001). "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub.". Biochem. Biophys. Res. Commun. 280 (2): 513–7. doi:10.1006/bbrc.2000.4151. PMID 11162547. 
  • Robinson RC, Turbedsky K, Kaiser DA, et al. (2001). "Crystal structure of Arp2/3 complex.". Science 294 (5547): 1679–84. doi:10.1126/science.1066333. PMID 11721045. 
  • Gournier H, Goley ED, Niederstrasser H, et al. (2002). "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.". Mol. Cell 8 (5): 1041–52. PMID 11741539. 
  • Millard TH, Behrendt B, Launay S, et al. (2003). "Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5.". Cell Motil. Cytoskeleton 54 (1): 81–90. doi:10.1002/cm.10087. PMID 12451597. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. 
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Rosentreter A, Hofmann A, Xavier CP, et al. (2007). "Coronin 3 involvement in F-actin-dependent processes at the cell cortex.". Exp. Cell Res. 313 (5): 878–95. doi:10.1016/j.yexcr.2006.12.015. PMID 17274980. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931. 
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