Arogenate dehydrogenase

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In enzymology, an arogenate dehydrogenase (EC 1.3.1.43) is an enzyme that catalyzes the chemical reaction

L-arogenate + NAD⁺ $\rightleftharpoons$ L-tyrosine + NADH + CO₂

Thus, the two substrates of this enzyme are L-arogenate and NAD⁺, whereas its 3 products are L-tyrosine, NADH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, pretyrosine dehydrogenase (ambiguous), and L-arogenate:NAD+ oxidoreductase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and novobiocin biosynthesis.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2F1K.

[edit] References

IUBMB entry for 1.3.1.43
BRENDA references for 1.3.1.43 (Recommended.)
PubMed references for 1.3.1.43
PubMed Central references for 1.3.1.43
Google Scholar references for 1.3.1.43
Stenmark SL, Pierson DL, Jensen RA, Glover GI (1974). "Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway". Nature. 247: 290–2. doi:10.1038/247290a0. PMID 4206476.
Byng G, Whitaker R, Flick C and Jensen RA (1981). "Enzymology of L-tyrosine biosynthesis in corn (Zea mays)". Phytochemistry 20: 1289–1292. doi:10.1016/0031-9422(81)80023-4.
Mayer E, Waldner-Sander S, Keller B, Keller E, Lingens F (1985). "Purification of arogenate dehydrogenase from Phenylobacterium immobile". FEBS. Lett. 179: 208–12. doi:10.1016/0014-5793(85)80519-6. PMID 3967752.
Lingens F, Keller E and Keller B (1987). "Arogenate dehydrogenase from Phenylobacterium immobile". Methods Enzymol. 142: 513–518.
Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA (1988). "Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa". J. Biol. Chem. 263: 17284–90. PMID 2972718.