Arogenate dehydratase

From Wikipedia, the free encyclopedia

In enzymology, an arogenate dehydratase (EC 4.2.1.91) is an enzyme that catalyzes the chemical reaction

L-arogenate L-phenylalanine + H₂O + CO₂

Hence, this enzyme has one substrate, L-arogenate, but 3 products: L-phenylalanine, H₂O, and CO₂.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming). Other names in common use include carboxycyclohexadienyl dehydratase, and L-arogenate hydro-lyase (decarboxylating). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.

[edit] References

• IUBMB entry for 4.2.1.91
• BRENDA references for 4.2.1.91 (Recommended.)
• PubMed references for 4.2.1.91
• PubMed Central references for 4.2.1.91
• Google Scholar references for 4.2.1.91
• Fischer R, Jensen R (1987). "Arogenate dehydratase". Methods. Enzymol. 142: 495–502. PMID 3600377. 
• Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA (1988). "Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa". J. Biol. Chem. 263: 17284–90. PMID 2972718. 
• Siehl DL, Conn EE (1988). "Kinetic and regulatory properties of arogenate dehydratase in seedlings of Sorghum bicolor (L.) Moench". Arch. Biochem. Biophys. 260: 822–9. PMID 3124763. 

[edit] External links

• IUBMB entry for 4.2.1.91

• KEGG entry for 4.2.1.91

• BRENDA entry for 4.2.1.91

• NiceZyme view of 4.2.1.91

• EC2PDB: PDB structures for 4.2.1.91

• PRIAM entry for 4.2.1.91

• PUMA2 entry for 4.2.1.91

• IntEnz: Integrated Enzyme entry for 4.2.1.91

• MetaCyc entry for 4.2.1.91

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047769: carboxycyclohexadienyl dehydratase

• AMIGO entry for GO code 0047769: carboxycyclohexadienyl dehydratase