ARNT2

From Wikipedia, the free encyclopedia

Aryl-hydrocarbon receptor nuclear translocator 2

Identifiers

ARNT2; KIAA0307

External IDs

OMIM: 606036 MGI: 107188 HomoloGene: 7230

Gene ontology
Molecular Function:	• transcription factor activity • signal transducer activity • aryl hydrocarbon receptor nuclear translocator activity • aryl hydrocarbon receptor binding • protein heterodimerization activity
Cellular Component:	• nucleus • transcription factor complex
Biological Process:	• response to hypoxia • in utero embryonic development • regulation of transcription, DNA-dependent • signal transduction • central nervous system development • response to xenobiotic stimulus • response to toxin • positive regulation of transcription • positive regulation of transcription from RNA polymerase II promoter

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014862 (mRNA)
NP_055677 (protein)

NM_007488 (mRNA)
NP_031514 (protein)

Location

Chr 15: 78.48 - 78.68 Mb

Chr 7: 84.12 - 84.25 Mb

Pubmed search

[1]

[2]

Aryl-hydrocarbon receptor nuclear translocator 2, also known as ARNT2, is a human gene.^[1]

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2.

[edit] Further reading

Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141-50. PMID 9205841.
Moffett P, Pelletier J (2000). "Different transcriptional properties of mSim-1 and mSim-2.". FEBS Lett. 466 (1): 80-6. PMID 10648817.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Wines ME, Lee L, Katari MS, et al. (2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.". Genomics 72 (1): 88-98. doi:10.1006/geno.2000.6466. PMID 11247670.
Barrow LL, Wines ME, Romitti PA, et al. (2003). "Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts.". Teratology 66 (2): 85-90. doi:10.1002/tera.10062. PMID 12210012.
Stolze I, Berchner-Pfannschmidt U, Freitag P, et al. (2002). "Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells.". Blood 100 (7): 2623-8. doi:10.1182/blood-2001-12-0169. PMID 12239177.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ooe N, Saito K, Mikami N, et al. (2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.". Mol. Cell. Biol. 24 (2): 608-16. PMID 14701734.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Friedman ER, Fan CM (2007). "Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.". Biochem. Biophys. Res. Commun. 363 (1): 113-8. doi:10.1016/j.bbrc.2007.08.108. PMID 17826745.