ARMET

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Arginine-rich, mutated in early stage tumors
Identifiers
Symbol(s) ARMET; ARP; MGC142148; MGC142150
External IDs OMIM: 601916 MGI: 1922090 HomoloGene: 4383
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7873 74840
Ensembl ENSG00000145050 ENSMUSG00000032575
Uniprot P55145 Q3TMX5
Refseq NM_006010 (mRNA)
NP_006001 (protein)		 NM_029103 (mRNA)
NP_083379 (protein)
Location Chr 3: 51.4 - 51.4 Mb Chr 9: 106.75 - 106.75 Mb
Pubmed search [1] [2]

Arginine-rich, mutated in early stage tumors, also known as ARMET, is a human gene.[1]

This gene encodes a highly conserved protein whose function is not yet known. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon.[1]

[edit] References

  1. ^ a b Entrez Gene: ARMET arginine-rich, mutated in early stage tumors.

[edit] Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566-9. doi:10.1038/nbt810. PMID 12665801. 
  • Lai MC, Kuo HW, Chang WC, Tarn WY (2003). "A novel splicing regulator shares a nuclear import pathway with SR proteins.". EMBO J. 22 (6): 1359-69. doi:10.1093/emboj/cdg126. PMID 12628928. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tanaka H, Shimada Y, Harada H, et al. (2000). "Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.". Oncol. Rep. 7 (3): 591-3. PMID 10767373. 
  • Shridhar V, Rivard S, Wang X, et al. (1997). "Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer.". Oncogene 14 (18): 2213-6. doi:10.1038/sj.onc.1201054. PMID 9174057. 
  • Shridhar R, Shridhar V, Rivard S, et al. (1997). "Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck.". Cancer Res. 56 (24): 5576-8. PMID 8971156. 
  • Shridhar V, Rivard S, Shridhar R, et al. (1996). "A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas.". Oncogene 12 (9): 1931-9. PMID 8649854. 
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