ARL4A

From Wikipedia, the free encyclopedia

ADP-ribosylation factor-like 4A

Identifiers

External IDs

OMIM: 604786 MGI: 99437 HomoloGene: 4194

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001037164 (mRNA)
NP_001032241 (protein)

NM_001039515 (mRNA)
NP_001034604 (protein)

Location

Chr 7: 12.69 - 12.7 Mb

Chr 12: 40.54 - 40.55 Mb

Pubmed search

[1]

[2]

ADP-ribosylation factor-like 4A, also known as ARL4A, is a human gene.^[1]

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARL4A ADP-ribosylation factor-like 4A.

[edit] Further reading

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42-50. doi:10.1006/geno.1994.1457. PMID 7829101.
Jacobs S, Schilf C, Fliegert F, et al. (1999). "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal.". FEBS Lett. 456 (3): 384-8. PMID 10462049.
Lin CY, Huang PH, Liao WL, et al. (2001). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli.". J. Biol. Chem. 275 (48): 37815-23. doi:10.1074/jbc.M002470200. PMID 10980193.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Hofmann I, Thompson A, Sanderson CM, Munro S (2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.". Curr. Biol. 17 (8): 711-6. doi:10.1016/j.cub.2007.03.007. PMID 17398095.