ARL1

From Wikipedia, the free encyclopedia

ADP-ribosylation factor-like 1

PDB rendering based on 1r4a.

Available structures: 1r4a, 1upt

Identifiers

Symbol(s)

ARL1; ARFL1

External IDs

OMIM: 603425 MGI: 99436 HomoloGene: 20319

Gene ontology
Molecular Function:	• nucleotide binding • GTPase activity • GTP binding • enzyme activator activity
Cellular Component:	• intracellular • Golgi apparatus
Biological Process:	• small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001177 (mRNA)
NP_001168 (protein)

NM_025859 (mRNA)
NP_080135 (protein)

Location

Chr 12: 100.31 - 100.33 Mb

Chr 10: 88.16 - 88.17 Mb

Pubmed search

[1]

[2]

ADP-ribosylation factor-like 1, also known as ARL1, is a human gene.^[1]

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARL1 ADP-ribosylation factor-like 1.

[edit] Further reading

Zhang GF, Patton WA, Lee FJ, et al. (1995). "Different ARF domains are required for the activation of cholera toxin and phospholipase D.". J. Biol. Chem. 270 (1): 21-4. PMID 7814376.
Hong JX, Lee FJ, Patton WA, et al. (1998). "Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1).". J. Biol. Chem. 273 (25): 15872-6. PMID 9624189.
Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23.". J. Biol. Chem. 274 (20): 14198-203. PMID 10318838.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Van Valkenburgh H, Shern JF, Sharer JD, et al. (2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.". J. Biol. Chem. 276 (25): 22826-37. doi:10.1074/jbc.M102359200. PMID 11303027.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi.". Mol. Biol. Cell 14 (9): 3767-81. doi:10.1091/mbc.E03-01-0864. PMID 12972563.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Lu L, Tai G, Hong W (2005). "Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network.". Mol. Biol. Cell 15 (10): 4426-43. doi:10.1091/mbc.E03-12-0872. PMID 15269279.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Zahn C, Hommel A, Lu L, et al. (2007). "Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.". Mol. Membr. Biol. 23 (6): 475-85. doi:10.1080/09687860600840100. PMID 17127620.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.