ARIH1

From Wikipedia, the free encyclopedia

Ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)

PDB rendering based on 1wd2.

Available structures: 1wd2

Identifiers

Symbol(s)

ARIH1; ARI; HARI; HHARI; UBCH7BP

External IDs

OMIM: 605624 MGI: 1344363 HomoloGene: 55924

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • small conjugating protein ligase activity • metal ion binding
Cellular Component:	• ubiquitin ligase complex
Biological Process:	• ubiquitin-dependent protein catabolic process • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005744 (mRNA)
NP_005735 (protein)

NM_019927 (mRNA)
NP_064311 (protein)

Location

Chr 15: 70.55 - 70.66 Mb

Chr 9: 59.19 - 59.28 Mb

Pubmed search

[1]

[2]

Ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila), also known as ARIH1, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARIH1 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila).

[edit] Further reading

Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1.". J. Biol. Chem. 274 (43): 30963–8. PMID 10521492.
Aguilera M, Oliveros M, Martínez-Padrón M, et al. (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.". Genetics 155 (3): 1231–44. PMID 10880484.
Zhang Y, Redina O, Altshuller YM, et al. (2001). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them.". J. Biol. Chem. 275 (45): 35224–32. doi:10.1074/jbc.M003329200. PMID 10926929.
Tan NG, Ardley HC, Rose SA, et al. (2001). "Characterisation of the human and mouse orthologues of the Drosophila ariadne gene.". Cytogenet. Cell Genet. 90 (3-4): 242–5. PMID 11124525.
Stanchi F, Bertocco E, Toppo S, et al. (2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences.". Yeast 18 (1): 69–80. doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H. PMID 11124703.
Ardley HC, Tan NG, Rose SA, et al. (2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7.". J. Biol. Chem. 276 (22): 19640–7. doi:10.1074/jbc.M011028200. PMID 11278816.
Wong ES, Fong CW, Lim J, et al. (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.". EMBO J. 21 (18): 4796–808. PMID 12234920.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Tan NG, Ardley HC, Scott GB, et al. (2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP.". FEBS Lett. 554 (3): 501–4. PMID 14623119.
Capili AD, Edghill EL, Wu K, Borden KL (2004). "Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING.". J. Mol. Biol. 340 (5): 1117–29. doi:10.1016/j.jmb.2004.05.035. PMID 15236971.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.