ARID5B

From Wikipedia, the free encyclopedia

AT rich interactive domain 5B (MRF1-like)

PDB rendering based on 1ig6.

Available structures: 1ig6

Identifiers

Symbol(s)

ARID5B; FLJ21150; MRF2

External IDs

OMIM: 608538 MGI: 2175912 HomoloGene: 45872

Gene ontology
Molecular Function:	• DNA binding • transcription repressor activity
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • negative regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

Refseq

NM_032199 (mRNA)
NP_115575 (protein)

XM_976508 (mRNA)
XP_981602 (protein)

Location

Chr 10: 63.33 - 63.53 Mb

Chr 10: 67.49 - 67.67 Mb

Pubmed search

[1]

[2]

AT rich interactive domain 5B (MRF1-like), also known as ARID5B, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARID5B AT rich interactive domain 5B (MRF1-like).

[edit] Further reading

Yuan YC, Whitson RH, Liu Q, et al. (1998). "A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases.". Nat. Struct. Biol. 5 (11): 959–64. doi:10.1038/2934. PMID 9808040.
Whitson RH, Huang T, Itakura K (1999). "The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts.". Biochem. Biophys. Res. Commun. 258 (2): 326–31. doi:10.1006/bbrc.1999.0643. PMID 10329386.
Zhu L, Hu J, Lin D, et al. (2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA.". Biochemistry 40 (31): 9142–50. PMID 11478881.
Lahoud MH, Ristevski S, Venter DJ, et al. (2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs.". Genome Res. 11 (8): 1327–34. doi:10.1101/gr.168801. PMID 11483573.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins.". Nucleic Acids Res. 33 (1): 66–80. doi:10.1093/nar/gki145. PMID 15640446.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.