ARHGEF9

From Wikipedia, the free encyclopedia

Cdc42 guanine nucleotide exchange factor (GEF) 9

PDB rendering based on 2dfk.

Available structures: 2dfk

Identifiers

Symbol(s)

ARHGEF9; COLLYBISTIN; HPEM-2; KIAA0424; PEM-2; PEM2

External IDs

OMIM: 300429 MGI: 2442233 HomoloGene: 9053

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity
Cellular Component:	• intracellular
Biological Process:	• regulation of Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015185 (mRNA)
NP_056000 (protein)

XM_981047 (mRNA)
XP_986141 (protein)

Location

Chr X: 62.77 - 62.92 Mb

Chr X: 91.25 - 91.33 Mb

Pubmed search

[1]

[2]

Cdc42 guanine nucleotide exchange factor (GEF) 9, also known as ARHGEF9, is a human gene.^[1]

ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state. These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9.

[edit] Further reading

Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Harvey K, Duguid IC, Alldred MJ, et al. (2004). "The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering.". J. Neurosci. 24 (25): 5816-26. doi:10.1523/JNEUROSCI.1184-04.2004. PMID 15215304.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Grosskreutz Y, Hermann A, Kins S, et al. (2002). "Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin.". Biol. Chem. 382 (10): 1455-62. PMID 11727829.
Kins S, Betz H, Kirsch J (2000). "Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin.". Nat. Neurosci. 3 (1): 22-9. doi:10.1038/71096. PMID 10607391.
Reid T, Bathoorn A, Ahmadian MR, Collard JG (1999). "Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42.". J. Biol. Chem. 274 (47): 33587-93. PMID 10559246.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307-13. PMID 9455477.