ARHGEF5

From Wikipedia, the free encyclopedia

Rho guanine nucleotide exchange factor (GEF) 5

Identifiers

ARHGEF5; DKFZp686N1969; GEF5; P60; TIM; TIM1

External IDs

OMIM: 600888 MGI: 1858952 HomoloGene: 66300

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • protein binding • GTP binding
Cellular Component:	• intracellular
Biological Process:	• regulation of Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_005435 (mRNA)
NP_005426 (protein)

XM_915627 (mRNA)
XP_920720 (protein)

Location

Chr 7: 143.69 - 143.71 Mb

Chr 6: 43.2 - 43.2 Mb

Pubmed search

[1]

[2]

Rho guanine nucleotide exchange factor (GEF) 5, also known as ARHGEF5, is a human gene.^[1]

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5.

[edit] Further reading

Takai S, Chan AM, Yamada K, Miki T (1995). "Assignment of the human TIM proto-oncogene to 7q33-->q35.". Cancer Genet. Cytogenet. 83 (1): 87-9. PMID 7656213.
Chan AM, McGovern ES, Catalano G, et al. (1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins.". Oncogene 9 (4): 1057-63. PMID 8134109.
Snyder JT, Worthylake DK, Rossman KL, et al. (2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.". Nat. Struct. Biol. 9 (6): 468-75. doi:10.1038/nsb796. PMID 12006984.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 171-84. PMID 12107413.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Umetsu DT, Dekruyff RH (2005). "Regulation of tolerance in the respiratory tract: TIM-1, hygiene, and the environment.". Ann. N. Y. Acad. Sci. 1029: 88-93. doi:10.1196/annals.1309.012. PMID 15681748.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785-95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240-50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.