ARHGEF4

From Wikipedia, the free encyclopedia

Rho guanine nucleotide exchange factor (GEF) 4

PDB rendering based on 2dx1.

Available structures: 2dx1

Identifiers

Symbol(s)

ARHGEF4; ASEF; GEF4; STM6

External IDs

OMIM: 605216 MGI: 2442507 HomoloGene: 49414

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity
Cellular Component:	• cellular_component • intracellular
Biological Process:	• intracellular signaling cascade • regulation of Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015320 (mRNA)
NP_056135 (protein)

NM_183019 (mRNA)
NP_898840 (protein)

Location

Chr 2: 131.39 - 131.52 Mb

Chr 1: 34.75 - 34.76 Mb

Pubmed search

[1]

[2]

Rho guanine nucleotide exchange factor (GEF) 4, also known as ARHGEF4, is a human gene.^[1]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Kuraguchi M, Wang XP, Bronson RT, et al. (2006). "Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.". PLoS Genet. 2 (9): e146. doi:10.1371/journal.pgen.0020146. PMID 17002498.
Watanabe T, Wang S, Noritake J, et al. (2005). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.". Dev. Cell 7 (6): 871-83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.
Kawasaki Y, Sato R, Akiyama T (2003). "Mutated APC and Asef are involved in the migration of colorectal tumour cells.". Nat. Cell Biol. 5 (3): 211-5. doi:10.1038/ncb937. PMID 12598901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kawasaki Y, Senda T, Ishidate T, et al. (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling.". Science 289 (5482): 1194-7. PMID 10947987.
Thiesen S, Kübart S, Ropers HH, Nothwang HG (2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22.". Biochem. Biophys. Res. Commun. 273 (1): 364-9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197-205. PMID 10470851.