ARHGEF11

From Wikipedia, the free encyclopedia

Rho guanine nucleotide exchange factor (GEF) 11

PDB rendering based on 1htj.

Available structures: 1htj, 1xcg, 2dls

Identifiers

Symbol(s)

ARHGEF11; DKFZp667F1223; GTRAP48; KIAA0380; PDZ-RHOGEF

External IDs

OMIM: 605708 MGI: 2441869 HomoloGene: 11409

Gene ontology
Molecular Function:	• signal transducer activity • guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • GTPase activator activity • protein binding
Cellular Component:	• intracellular
Biological Process:	• cytokinesis • regulation of cell growth • cell motility • striated muscle contraction • G-protein coupled receptor protein signaling pathway • establishment of cell polarity • actin cytoskeleton organization and biogenesis • regulation of Rho protein signal transduction • positive regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_014784 (mRNA)
NP_055599 (protein)

XM_986202 (mRNA)
XP_991296 (protein)

Location

Chr 1: 155.17 - 155.28 Mb

n/a

Pubmed search

[1]

[2]

Rho guanine nucleotide exchange factor (GEF) 11, also known as ARHGEF11, is a human gene.^[1]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11.

[edit] Further reading

Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Fukuhara S, Murga C, Zohar M, et al. (1999). "A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.". J. Biol. Chem. 274 (9): 5868–79. PMID 10026210.
Rümenapp U, Blomquist A, Schwörer G, et al. (1999). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member.". FEBS Lett. 459 (3): 313–8. PMID 10526156.
Togashi H, Nagata K, Takagishi M, et al. (2000). "Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization.". J. Biol. Chem. 275 (38): 29570–8. doi:10.1074/jbc.M003726200. PMID 10900204.
Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins.". Nature 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047.
Longenecker KL, Lewis ME, Chikumi H, et al. (2001). "Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.". Structure 9 (7): 559–69. PMID 11470431.
Perrot V, Vazquez-Prado J, Gutkind JS (2003). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.". J. Biol. Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
Driessens MH, Olivo C, Nagata K, et al. (2002). "B plexins activate Rho through PDZ-RhoGEF.". FEBS Lett. 529 (2-3): 168–72. PMID 12372594.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Barac A, Basile J, Vázquez-Prado J, et al. (2004). "Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor.". J. Biol. Chem. 279 (7): 6182–9. doi:10.1074/jbc.M309579200. PMID 14625312.
Davidkova G, McCullumsmith RE, Meador-Woodruff JH (2004). "Expression of ARHGEF11 mRNA in schizophrenic thalamus.". Ann. N. Y. Acad. Sci. 1003: 375–7. PMID 14684465.
Banerjee J, Wedegaertner PB (2004). "Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton.". Mol. Biol. Cell 15 (4): 1760–75. doi:10.1091/mbc.E03-07-0527. PMID 14742719.
Wang Q, Liu M, Kozasa T, et al. (2004). "Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.". J. Biol. Chem. 279 (28): 28831–4. doi:10.1074/jbc.C400105200. PMID 15143072.
Guo X, Li Y, Peng K, et al. (2006). "Solution structures and backbone dynamics of arsenate reductase from Bacillus subtilis: reversible conformational switch associated with arsenate reduction.". J. Biol. Chem. 280 (47): 39601–8. doi:10.1074/jbc.M508132200. PMID 16192272.
Longhurst DM, Watanabe M, Rothstein JD, Jackson M (2006). "Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity.". J. Biol. Chem. 281 (17): 12030–40. doi:10.1074/jbc.M513756200. PMID 16478718.
Gu J, Wu X, Dong Q, et al. (2006). "A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.". Cancer 106 (12): 2716–24. doi:10.1002/cncr.21944. PMID 16691626.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ma L, Hanson RL, Que LN, et al. (2007). "Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.". Diabetes 56 (5): 1454–9. doi:10.2337/db06-0640. PMID 17287471.