ARHGEF10

From Wikipedia, the free encyclopedia

Rho guanine nucleotide exchange factor (GEF) 10

Identifiers

ARHGEF10; DKFZp686H0726; GEF10; MGC131664

External IDs

OMIM: 608136 MGI: 2444453 HomoloGene: 22827

Gene ontology
Molecular Function:	• guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity
Cellular Component:	• intracellular
Biological Process:	• regulation of Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014629 (mRNA)
NP_055444 (protein)

NM_001037736 (mRNA)
NP_001032825 (protein)

Location

Chr 8: 1.76 - 1.89 Mb

Chr 8: 14.91 - 15 Mb

Pubmed search

[1]

[2]

Rho guanine nucleotide exchange factor (GEF) 10, also known as ARHGEF10, is a human gene.^[1]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Jungerius BJ, Hoogendoorn ML, Bakker SC, et al.. "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia.". doi:10.1038/sj.mp.4002080. PMID 17893707.
Mohl M, Winkler S, Wieland T, Lutz S (2007). "Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture.". Naunyn Schmiedebergs Arch. Pharmacol. 373 (5): 333-41. doi:10.1007/s00210-006-0083-0. PMID 16896804.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707-16. doi:10.1038/nbt971. PMID 15146197.
Verhoeven K, De Jonghe P, Van de Putte T, et al. (2003). "Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10.". Am. J. Hum. Genet. 73 (4): 926-32. doi:10.1086/378159. PMID 14508709.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ranta S, Lehesjoki AE, de Fatima Bonaldo M, et al. (1997). "High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p.". Genome Res. 7 (9): 887-96. PMID 9314494.
Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141-50. PMID 9205841.