ARHGDIG

From Wikipedia, the free encyclopedia

Rho GDP dissociation inhibitor (GDI) gamma

Identifiers

External IDs

OMIM: 602844 MGI: 108430 HomoloGene: 7337

Gene ontology
Molecular Function:	• Rho GDP-dissociation inhibitor activity • GTPase activator activity
Cellular Component:	• cytoplasm • cytoplasmic membrane-bound vesicle
Biological Process:	• negative regulation of cell adhesion • Rho protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001176 (mRNA)
NP_001167 (protein)

NM_008113 (mRNA)
NP_032139 (protein)

Location

Chr 16: 0.27 - 0.27 Mb

n/a

Pubmed search

[1]

[2]

Rho GDP dissociation inhibitor (GDI) gamma, also known as ARHGDIG, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Zalcman G, Closson V, Camonis J, et al. (1997). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG.". J. Biol. Chem. 271 (48): 30366–74. PMID 8939998.
Adra CN, Manor D, Ko JL, et al. (1997). "RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4279–84. PMID 9113980.
Adra CN, Iyengar AR, Syed FA, et al. (1998). "Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3.". Genomics 53 (1): 104–9. PMID 9787082.
Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes.". Immunogenetics 49 (10): 835–42. PMID 10436176.
Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. PMID 11157797.
Li X, Bu X, Lu B, et al. (2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.". Mol. Cell. Biol. 22 (4): 1158–71. PMID 11809807.
Brunet N, Morin A, Olofsson B (2002). "RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain.". Traffic 3 (5): 342–57. PMID 11967128.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
del Pozo MA, Alderson NB, Kiosses WB, et al. (2004). "Integrins regulate Rac targeting by internalization of membrane domains.". Science 303 (5659): 839–42. doi:10.1126/science.1092571. PMID 14764880.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Dransart E, Morin A, Cherfils J, Olofsson B (2005). "Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.". J. Biol. Chem. 280 (6): 4674–83. doi:10.1074/jbc.M409741200. PMID 15513926.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.