ARHGDIB

From Wikipedia, the free encyclopedia

Rho GDP dissociation inhibitor (GDI) beta

PDB rendering based on 1ds6.

Available structures: 1ds6

Identifiers

Symbol(s)

ARHGDIB; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1

External IDs

OMIM: 602843 MGI: 101940 HomoloGene: 20318

Gene ontology
Molecular Function:	• Rho GDP-dissociation inhibitor activity • GTPase activator activity • protein binding
Cellular Component:	• cytoplasm • cytoskeleton • cytoplasmic membrane-bound vesicle
Biological Process:	• cell motility • immune response • negative regulation of cell adhesion • Rho protein signal transduction • multicellular organismal development • actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001175 (mRNA)
NP_001166 (protein)

NM_007486 (mRNA)
NP_031512 (protein)

Location

Chr 12: 14.99 - 15.01 Mb

Chr 6: 136.89 - 136.91 Mb

Pubmed search

[1]

[2]

Rho GDP dissociation inhibitor (GDI) beta, also known as ARHGDIB, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARHGDIB Rho GDP dissociation inhibitor (GDI) beta.

[edit] Further reading

Aebersold R, Leavitt J (1990). "Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database.". Electrophoresis 11 (7): 517-27. doi:10.1002/elps.1150110702. PMID 2226408.
Shisheva A, Südhof TC, Czech MP (1994). "Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.". Mol. Cell. Biol. 14 (5): 3459-68. PMID 7513052.
Adra CN, Kobayashi H, Rowley JD, Lim B (1995). "Assignment of the human GDID4 gene, a GDP/GTP-exchange regulator, to chromosome 12p12.3.". Genomics 24 (1): 188-90. doi:10.1006/geno.1994.1601. PMID 7896279.
Leffers H, Nielsen MS, Andersen AH, et al. (1994). "Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.". Exp. Cell Res. 209 (2): 165-74. doi:10.1006/excr.1993.1298. PMID 8262133.
Scherle P, Behrens T, Staudt LM (1993). "Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7568-72. PMID 8356058.
Lelias JM, Adra CN, Wulf GM, et al. (1993). "cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins.". Proc. Natl. Acad. Sci. U.S.A. 90 (4): 1479-83. PMID 8434008.
Adra CN, Manor D, Ko JL, et al. (1997). "RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4279-84. PMID 9113980.
Takahashi K, Sasaki T, Mammoto A, et al. (1997). "Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein.". J. Biol. Chem. 272 (37): 23371-5. PMID 9287351.
Gorvel JP, Chang TC, Boretto J, et al. (1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity.". FEBS Lett. 422 (2): 269-73. PMID 9490022.
Illenberger D, Schwald F, Pimmer D, et al. (1999). "Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.". EMBO J. 17 (21): 6241-9. doi:10.1093/emboj/17.21.6241. PMID 9799233.
Scheffzek K, Stephan I, Jensen ON, et al. (2000). "The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.". Nat. Struct. Biol. 7 (2): 122-6. doi:10.1038/72392. PMID 10655614.
Groysman M, Russek CS, Katzav S (2000). "Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation.". FEBS Lett. 467 (1): 75-80. PMID 10664460.
Kasper B, Tidow N, Grothues D, Welte K (2000). "Differential expression and regulation of GTPases (RhoA and Rac2) and GDIs (LyGDI and RhoGDI) in neutrophils from patients with severe congenital neutropenia.". Blood 95 (9): 2947-53. PMID 10779444.
Fauré J, Dagher MC (2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI).". Biochimie 83 (5): 409-14. PMID 11368848.
Li X, Bu X, Lu B, et al. (2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.". Mol. Cell. Biol. 22 (4): 1158-71. PMID 11809807.
Kwon KB, Park EK, Ryu DG, Park BH (2003). "D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells.". Exp. Mol. Med. 34 (1): 32-7. PMID 11989976.
Thiede B, Siejak F, Dimmler C, Rudel T (2003). "Prediction of translocation and cleavage of heterogeneous ribonuclear proteins and Rho guanine nucleotide dissociation inhibitor 2 during apoptosis by subcellular proteome analysis.". Proteomics 2 (8): 996-1006. doi:10.1002/1615-9861(200208)2:8<996::AID-PROT996>3.0.CO;2-3. PMID 12203895.
Groysman M, Hornstein I, Alcover A, Katzav S (2003). "Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways.". J. Biol. Chem. 277 (51): 50121-30. doi:10.1074/jbc.M204299200. PMID 12386169.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.