ARHGAP9

From Wikipedia, the free encyclopedia


Rho GTPase activating protein 9
PDB rendering based on 2p0d.
Available structures: 2p0d, 2p0f, 2p0h
Identifiers
Symbol(s) ARHGAP9; RGL1; 10C; FLJ16525; MGC1295
External IDs OMIM: 610576 HomoloGene: 13041
Orthologs
Human Mouse
Entrez 64333 n/a
Ensembl ENSG00000123329 n/a
Uniprot Q9BRR9 n/a
Refseq NM_001080156 (mRNA)
NP_001073625 (protein)		 n/a (mRNA)
n/a (protein)
Location Chr 12: 56.15 - 56.16 Mb n/a
Pubmed search [1] n/a

Rho GTPase activating protein 9, also known as ARHGAP9, is a human gene.[1]

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: ARHGAP9 Rho GTPase activating protein 9.

[edit] Further reading

  • Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships.". FEBS Lett. 528 (1-3): 27-34. PMID 12297274. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324-32. doi:10.1101/gr.2334104. PMID 15231748. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Furukawa Y, Kawasoe T, Daigo Y, et al. (2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein.". Biochem. Biophys. Res. Commun. 284 (3): 643-9. doi:10.1006/bbrc.2001.5022. PMID 11396949. 
 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it.