ARHGAP8

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Rho GTPase activating protein 8
Identifiers
Symbol(s) ARHGAP8; BPGAP1; FLJ20185; PP610
External IDs OMIM: 609405 MGI: 1920417 HomoloGene: 23645
Orthologs
Human Mouse
Entrez 23779 73167


Refseq NM_001017526 (mRNA)
NP_001017526 (protein)		 NM_028455 (mRNA)
NP_082731 (protein)
Pubmed search [1] [2]

Rho GTPase activating protein 8, also known as ARHGAP8, is a human gene.[1]

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.[1]

[edit] References

  1. ^ a b Entrez Gene: ARHGAP8 Rho GTPase activating protein 8.

[edit] Further reading

  • Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships.". FEBS Lett. 528 (1-3): 27–34. PMID 12297274. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Shan Z, Haaf T, Popescu NC (2003). "Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8.". Gene 303: 55–61. PMID 12559566. 
  • Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.". J. Biol. Chem. 278 (46): 45903–14. doi:10.1074/jbc.M304514200. PMID 12944407. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Lua BL, Low BC (2004). "BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration.". Mol. Biol. Cell 15 (6): 2873–83. doi:10.1091/mbc.E04-02-0141. PMID 15064355. 
  • Johnstone CN, Castellví-Bel S, Chang LM, et al. (2004). "ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers.". Gene 336 (1): 59–71. doi:10.1016/j.gene.2004.01.025. PMID 15225876. 
  • Lua BL, Low BC (2005). "Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration.". Biochem. Soc. Trans. 32 (Pt 6): 1110–2. doi:10.1042/BST0321110. PMID 15506981. 
  • Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain.". J. Cell. Sci. 118 (Pt 12): 2707–21. doi:10.1242/jcs.02383. PMID 15944398. 
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