ARHGAP26

From Wikipedia, the free encyclopedia

Rho GTPase activating protein 26

PDB rendering based on 1f7c.

Available structures: 1f7c, 1ugv

Identifiers

Symbol(s)

ARHGAP26; FLJ42530; GRAF; KIAA0621; OPHN1L; OPHN1L1

External IDs

OMIM: 605370 MGI: 1918552 HomoloGene: 36349

Gene ontology
Molecular Function:	• GTPase activator activity • Rho GTPase activator activity
Cellular Component:	• cellular_component • intracellular
Biological Process:	• signal transduction • nervous system development • actin cytoskeleton organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_015071 (mRNA)
NP_055886 (protein)

XM_988482 (mRNA)
XP_993576 (protein)

Location

Chr 5: 142.13 - 142.59 Mb

Chr 18: 39.12 - 39.5 Mb

Pubmed search

[1]

[2]

Rho GTPase activating protein 26, also known as ARHGAP26, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARHGAP26 Rho GTPase activating protein 26.

[edit] Further reading

Ramakers GJ (2002). "Rho proteins, mental retardation and the cellular basis of cognition.". Trends Neurosci. 25 (4): 191–9. PMID 11998687.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Shibata H, Oishi K, Yamagiwa A, et al. (2001). "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family.". J. Biochem. 130 (1): 23–31. PMID 11432776.
Borkhardt A, Bojesen S, Haas OA, et al. (2000). "The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q.". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9168–73. doi:10.1073/pnas.150079597. PMID 10908648.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Taylor JM, Macklem MM, Parsons JT (1999). "Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho.". J. Cell. Sci. 112 ( Pt 2): 231–42. PMID 9858476.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Billuart P, Bienvenu T, Ronce N, et al. (1998). "Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation.". Nature 392 (6679): 923–6. doi:10.1038/31940. PMID 9582072.
Taylor JM, Hildebrand JD, Mack CP, et al. (1998). "Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase.". J. Biol. Chem. 273 (14): 8063–70. PMID 9525907.
Hildebrand JD, Taylor JM, Parsons JT (1996). "An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase.". Mol. Cell. Biol. 16 (6): 3169–78. PMID 8649427.
Pillay TS, Sasaoka T, Olefsky JM (1995). "Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase.". J. Biol. Chem. 270 (3): 991–4. PMID 7836419.