Arginine vasopressin receptor 1A

From Wikipedia, the free encyclopedia


Arginine vasopressin receptor 1A
Identifiers
Symbol(s) AVPR1A; AVPR1
External IDs OMIM: 600821 MGI: 1859216 HomoloGene: 568
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 552 54140
Ensembl ENSG00000166148 ENSMUSG00000020123
Uniprot P37288 Q3U1H9
Refseq NM_000706 (mRNA)
NP_000697 (protein)		 NM_016847 (mRNA)
NP_058543 (protein)
Location Chr 12: 61.83 - 61.83 Mb Chr 10: 121.85 - 121.86 Mb
Pubmed search [1] [2]

Arginine vasopressin receptor 1A (AVPR1A) is a protein that acts as receptor for arginine vasopressin.[1] AVPR1A belongs to the subfamily of G-protein coupled receptors.

Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

The activity / genetic variants of the AVPR1 gene might be related to generosity and altruistic behavior.[2]

[edit] References

  1. ^ Thibonnier M, Auzan C, Madhun Z, Wilkins P, Berti-Mattera L, Clauser E (1994). "Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor". J. Biol. Chem. 269 (5): 3304–10. PMID 8106369. 
  2. ^ Knafo A, Israel S, Darvasi A, Bachner-Melman R, Uzefovsky F, Cohen L, Feldman E, Lerer E, Laiba E, Raz Y, Nemanov L, Gritsenko I, Dina C, Agam G, Dean B, Bornstein G, Ebstein RP (2007). "Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA". Genes Brain Behav. doi:10.1111/j.1601-183X.2007.00341.x. PMID 17696996. 

[edit] Further reading

  • Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Molecular pharmacology and modeling of vasopressin receptors.". Prog. Brain Res. 139: 179–96. PMID 12436935. 
  • Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column.". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. 
  • Hirasawa A, Shibata K, Kotosai K, Tsujimoto G (1994). "Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor.". Biochem. Biophys. Res. Commun. 203 (1): 72–9. doi:10.1006/bbrc.1994.2150. PMID 8074728. 
  • Thibonnier M, Auzan C, Madhun Z, et al. (1994). "Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.". J. Biol. Chem. 269 (5): 3304–10. PMID 8106369. 
  • Young WS, Kovács K, Lolait SJ (1993). "The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin.". Endocrinology 133 (2): 585–90. PMID 8344200. 
  • Thibonnier M, Graves MK, Wagner MS, et al. (1997). "Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene.". Genomics 31 (3): 327–34. doi:10.1006/geno.1996.0055. PMID 8838314. 
  • North WG, Fay MJ, Longo K, Du J (1998). "Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.". Peptides 18 (7): 985–93. PMID 9357056. 
  • North WG, Fay MJ, Longo KA, Du J (1998). "Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.". Cancer Res. 58 (9): 1866–71. PMID 9581826. 
  • North WG, Fay MJ, Du J (1999). "MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R.". Peptides 20 (7): 837–42. PMID 10477084. 
  • Tahara A, Tsukada J, Ishii N, et al. (1999). "Comparison of vasopressin binding sites in human uterine and vascular smooth muscle cells.". Eur. J. Pharmacol. 378 (1): 137–42. PMID 10478574. 
  • Thibonnier M, Graves MK, Wagner MS, et al. (2000). "Study of V(1)-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension.". J. Mol. Cell. Cardiol. 32 (4): 557–64. doi:10.1006/jmcc.2000.1108. PMID 10756113. 
  • Berrada K, Plesnicher CL, Luo X, Thibonnier M (2000). "Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation.". J. Biol. Chem. 275 (35): 27229–37. doi:10.1074/jbc.M002288200. PMID 10858434. 
  • Kim SJ, Young LJ, Gonen D, et al. (2002). "Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism.". Mol. Psychiatry 7 (5): 503–7. doi:10.1038/sj.mp.4001125. PMID 12082568. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Tahtaoui C, Balestre MN, Klotz P, et al. (2003). "Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors.". J. Biol. Chem. 278 (41): 40010–9. doi:10.1074/jbc.M301128200. PMID 12869559. 
  • Hawtin SR, Wesley VJ, Simms J, et al. (2004). "An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist.". Eur. J. Biochem. 270 (23): 4681–8. PMID 14622255. 
  • Terrillon S, Barberis C, Bouvier M (2004). "Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns.". Proc. Natl. Acad. Sci. U.S.A. 101 (6): 1548–53. doi:10.1073/pnas.0305322101. PMID 14757828. 
  • Wassink TH, Piven J, Vieland VJ, et al. (2005). "Examination of AVPR1a as an autism susceptibility gene.". Mol. Psychiatry 9 (10): 968–72. doi:10.1038/sj.mp.4001503. PMID 15098001. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 

[edit] External links

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like
Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 177, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like
Class C: Metabotropic
glutamate / pheromone
Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened
v • d • e
Neuropeptide receptors
Hypothalamic hormone receptors
Pituitary hormone receptors
Other hormone receptors
Opioid receptors
Other neuropeptide receptors
 This membrane protein-related article is a stub. You can help Wikipedia by expanding it.