Arginine N-succinyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an arginine N-succinyltransferase (EC 2.3.1.109) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + L-arginine CoA + N₂-succinyl-L-arginine

Thus, the two substrates of this enzyme are succinyl-CoA and L-arginine, whereas its two products are CoA and N2-succinyl-L-arginine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-arginine N2-succinyltransferase. Other names in common use include arginine succinyltransferase, AstA, arginine and ornithine N2-succinyltransferase, AOST, AST, and succinyl-CoA:L-arginine 2-N-succinyltransferase. This enzyme participates in arginine and proline metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1YLE.

[edit] References

• IUBMB entry for 2.3.1.109
• BRENDA references for 2.3.1.109 (Recommended.)
• PubMed references for 2.3.1.109
• PubMed Central references for 2.3.1.109
• Google Scholar references for 2.3.1.109
• Vander Wauven C, Jann A, Haas D, Leisinger T, Stalon V (1988). "N2-succinylornithine in ornithine catabolism of Pseudomonas aeruginosa". Arch. Microbiol. 150: 400–4. doi:10.1007/BF00408314. PMID 3144259. 
• Vander Wauven C, Stalon V (1985). "Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia". J. Bacteriol. 164: 882–6. PMID 2865249. 
• Tricot C, Vander Wauven C, Wattiez R, Falmagne P, Stalon V (1994). "Purification and properties of a succinyltransferase from Pseudomonas aeruginosa specific for both arginine and ornithine". Eur. J. Biochem. 224: 853–61. doi:10.1111/j.1432-1033.1994.00853.x. PMID 7523119. 
• Itoh Y (1997). "Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa". J. Bacteriol. 179: 7280–90. PMID 9393691. 
• Schneider BL, Kiupakis AK, Reitzer LJ (1998). "Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli". J. Bacteriol. 180: 4278–86. PMID 9696779. 
• Cunin R, Glansdorff N, Pierard A, Stalon V (1986). "Biosynthesis and metabolism of arginine in bacteria". Microbiol. Rev. 50: 314–52. PMID 3534538. 
• Cunin R, Glansdorff N, Pierard A and Stalon V (1987). "Erratum report: Biosynthesis and metabolism of arginine in bacteria". Microbiol. Rev. 51: 178. 

[edit] External links

The CAS registry number for this enzyme class is 99676-48-9.

• IUBMB entry for 2.3.1.109

• KEGG entry for 2.3.1.109

• BRENDA entry for 2.3.1.109

• NiceZyme view of 2.3.1.109

• EC2PDB: PDB structures for 2.3.1.109

• PRIAM entry for 2.3.1.109

• PUMA2 entry for 2.3.1.109

• IntEnz: Integrated Enzyme entry for 2.3.1.109

• MetaCyc entry for 2.3.1.109

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008791: arginine N-succinyltransferase

• AMIGO entry for GO code 0008791: arginine N-succinyltransferase