Arginine 2-monooxygenase

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In enzymology, an arginine 2-monooxygenase (EC 1.13.12.1) is an enzyme that catalyzes the chemical reaction

L-arginine + O₂ $\rightleftharpoons$ 4-guanidinobutanamide + CO₂ + H₂O

Thus, the two substrates of this enzyme are L-arginine and O₂, whereas its 3 products are 4-guanidinobutanamide, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-arginine:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include arginine monooxygenase, arginine decarboxylase, arginine oxygenase (decarboxylating), and arginine decarboxy-oxidase. This enzyme participates in urea cycle and metabolism of amino groups. It has one cofactor: the flavin FAD.

[edit] References

IUBMB entry for 1.13.12.1
BRENDA references for 1.13.12.1 (Recommended.)
PubMed references for 1.13.12.1
PubMed Central references for 1.13.12.1
Google Scholar references for 1.13.12.1
Olomucki A, Pho DB, Lebar R, Delcambe L, Thoai NV (1968). "[Arginine oxygenase (decarboxylating). V. Purification and flavin nature]". Biochim. Biophys. Acta. 151: 353–66. PMID 4295160.
Thoai NV and Olomucki A (1962). "Arginine decarboxy-oxydase. I. Caracteres et nature de l'enzyme". Biochim. Biophys. Acta 59: 533–544. doi:10.1016/0006-3002(62)90631-5.
Thoai NV and Olomucki A (1962). "Arginine decarboxy-oxydase. II. Oxydation de la canavanine et de l'homoarginine en beta-guanidopropionamide et en delta-guanidovaleramide". Biochim. Biophys. Acta 59: 545–552.