ARFIP2

From Wikipedia, the free encyclopedia

ADP-ribosylation factor interacting protein 2 (arfaptin 2)

PDB rendering based on 1i49.

Available structures: 1i49, 1i4d, 1i4l, 1i4t

Identifiers

Symbol(s)

ARFIP2; POR1

External IDs

OMIM: 601638 MGI: 1924182 HomoloGene: 8234

Gene ontology
Molecular Function:	• GTP binding • GTP-dependent protein binding • Rac GTPase binding
Cellular Component:	• ruffle • cytoplasm • plasma membrane • cell cortex
Biological Process:	• cell motility • small GTPase mediated signal transduction • lamellipodium biogenesis • actin cytoskeleton organization and biogenesis • ruffle organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012402 (mRNA)
NP_036534 (protein)

NM_029802 (mRNA)
NP_084078 (protein)

Location

Chr 11: 6.45 - 6.46 Mb

Chr 7: 105.51 - 105.51 Mb

Pubmed search

[1]

[2]

ADP-ribosylation factor interacting protein 2 (arfaptin 2), also known as ARFIP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2).

[edit] Further reading

Van Aelst L, Joneson T, Bar-Sagi D (1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling.". EMBO J. 15 (15): 3778–86. PMID 8670882.
Kanoh H, Williger BT, Exton JH (1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes.". J. Biol. Chem. 272 (9): 5421–9. PMID 9038142.
D'Souza-Schorey C, Boshans RL, McDonough M, et al. (1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.". EMBO J. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMID 9312003.
Tarricone C, Xiao B, Justin N, et al. (2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.". Nature 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.
Shin OH, Exton JH (2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1.". Biochem. Biophys. Res. Commun. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
Peters PJ, Ning K, Palacios F, et al. (2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein.". Nat. Cell Biol. 4 (3): 240–5. doi:10.1038/ncb761. PMID 11854752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi.". Mol. Biol. Cell 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMID 12972563.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rangone H, Pardo R, Colin E, et al. (2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.". J. Biol. Chem. 280 (23): 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.