ARFGEF2

From Wikipedia, the free encyclopedia

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Identifiers

ARFGEF2; BIG2; FLJ23723; dJ1164I10.1

External IDs

OMIM: 605371 MGI: 2139354 HomoloGene: 21287

Gene ontology
Molecular Function:	• ARF guanyl-nucleotide exchange factor activity
Cellular Component:	• Golgi membrane • intracellular • cytosol • membrane
Biological Process:	• exocytosis • intracellular signaling cascade • regulation of ARF protein signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_006420 (mRNA)
NP_006411 (protein)

XM_130646 (mRNA)
XP_130646 (protein)

Location

Chr 20: 46.97 - 47.09 Mb

n/a

Pubmed search

[1]

[2]

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited), also known as ARFGEF2, is a human gene.^[1]

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.^[1]

[edit] References

^ ^a ^b Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited).

[edit] Further reading

Togawa A, Morinaga N, Ogasawara M, et al. (1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.". J. Biol. Chem. 274 (18): 12308–15. PMID 10212200.
Yamaji R, Adamik R, Takeda K, et al. (2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2567–72. PMID 10716990.
Kamei Y, Takeda Y, Teramoto K, et al. (2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.". Genomics 69 (1): 113–9. doi:10.1006/geno.2000.6310. PMID 11013081.
Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors.". Meth. Enzymol. 345: 397–404. PMID 11665623.
Shinotsuka C, Yoshida Y, Kawamoto K, et al. (2002). "Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation.". J. Biol. Chem. 277 (11): 9468–73. doi:10.1074/jbc.M112427200. PMID 11777925.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Shinotsuka C, Waguri S, Wakasugi M, et al. (2002). "Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins.". Biochem. Biophys. Res. Commun. 294 (2): 254–60. doi:10.1016/S0006-291X(02)00456-4. PMID 12051703.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Li H, Adamik R, Pacheco-Rodriguez G, et al. (2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMID 12571360.
Sheen VL, Ganesh VS, Topcu M, et al. (2004). "Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex.". Nat. Genet. 36 (1): 69–76. doi:10.1038/ng1276. PMID 14647276.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Xu KF, Shen X, Li H, et al. (2005). "Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70.". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2784–9. doi:10.1073/pnas.0409871102. PMID 15705715.
Lu J, Tiao G, Folkerth R, et al. (2006). "Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia.". J. Comp. Neurol. 494 (3): 476–84. doi:10.1002/cne.20806. PMID 16320251.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Islam A, Shen X, Hiroi T, et al. (2007). "The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles.". J. Biol. Chem. 282 (13): 9591–9. doi:10.1074/jbc.M607122200. PMID 17276987.
Kuroda F, Moss J, Vaughan M (2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3201–6. doi:10.1073/pnas.0611696104. PMID 17360629.