ARD1A

From Wikipedia, the free encyclopedia

ARD1 homolog A, N-acetyltransferase (S. cerevisiae)

Identifiers

ARD1A; ARD1; DXS707; MGC71248; TE2

External IDs

OMIM: 300013 MGI: 1915255 HomoloGene: 2608

Gene ontology
Molecular Function:	• peptide alpha-N-acetyltransferase activity • protein binding • N-acetyltransferase activity • transferase activity • ribosome binding
Cellular Component:	• intracellular • nucleus • cytoplasm
Biological Process:	• DNA packaging • N-terminal protein amino acid acetylation • internal protein amino acid acetylation • chromosome organization and biogenesis (sensu Eukaryota)

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003491 (mRNA)
NP_003482 (protein)

NM_019870 (mRNA)
NP_063923 (protein)

Location

Chr X: 152.85 - 152.85 Mb

Chr X: 70.17 - 70.17 Mb

Pubmed search

[1]

[2]

ARD1 homolog A, N-acetyltransferase (S. cerevisiae), also known as ARD1A, is a human gene.^[1]

[edit] References

^ Entrez Gene: ARD1A ARD1 homolog A, N-acetyltransferase (S. cerevisiae).

[edit] Further reading

Tribioli C, Mancini M, Plassart E, et al. (1995). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae.". Hum. Mol. Genet. 3 (7): 1061-7. PMID 7981673.
Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse.". Genomics 44 (1): 8-14. doi:10.1006/geno.1997.4822. PMID 9286695.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Jeong JW, Bae MK, Ahn MY, et al. (2003). "Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.". Cell 111 (5): 709-20. PMID 12464182.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sugiura N, Adams SM, Corriveau RA (2003). "An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development.". J. Biol. Chem. 278 (41): 40113-20. doi:10.1074/jbc.M301218200. PMID 12888564.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336.
Arnesen T, Anderson D, Baldersheim C, et al. (2005). "Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.". Biochem. J. 386 (Pt 3): 433-43. doi:10.1042/BJ20041071. PMID 15496142.
Asaumi M, Iijima K, Sumioka A, et al. (2005). "Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion.". J. Biochem. 137 (2): 147-55. doi:10.1093/jb/mvi014. PMID 15749829.
Fisher TS, Etages SD, Hayes L, et al. (2005). "Analysis of ARD1 function in hypoxia response using retroviral RNA interference.". J. Biol. Chem. 280 (18): 17749-57. doi:10.1074/jbc.M412055200. PMID 15755738.
Bilton R, Mazure N, Trottier E, et al. (2005). "Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF.". J. Biol. Chem. 280 (35): 31132-40. doi:10.1074/jbc.M504482200. PMID 15994306.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Arnesen T, Gromyko D, Horvli O, et al. (2006). "Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.". Thyroid 15 (10): 1131-6. doi:10.1089/thy.2005.15.1131. PMID 16279846.
Arnesen T, Kong X, Evjenth R, et al. (2006). "Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha.". FEBS Lett. 579 (28): 6428-32. doi:10.1016/j.febslet.2005.10.036. PMID 16288748.
Kim SH, Park JA, Kim JH, et al. (2006). "Characterization of ARD1 variants in mammalian cells.". Biochem. Biophys. Res. Commun. 340 (2): 422-7. doi:10.1016/j.bbrc.2005.12.018. PMID 16376303.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901.
Arnesen T, Gromyko D, Pendino F, et al. (2006). "Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex.". Oncogene 25 (31): 4350-60. doi:10.1038/sj.onc.1209469. PMID 16518407.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.