Aralkylamine N-acetyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an aralkylamine N-acetyltransferase (EC 2.3.1.87) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + a 2-arylethylamine $\rightleftharpoons$ CoA + an N-acetyl-2-arylethylamine

Thus, the two substrates of this enzyme are acetyl-CoA and 2-arylethylamine, whereas its two products are CoA and N-acetyl-2-arylethylamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:2-arylethylamine N-acetyltransferase. Other names in common use include serotonin acetyltransferase, serotonin acetylase, arylalkylamine N-acetyltransferase, serotonin N-acetyltransferase, AANAT, and melatonin rhythm enzyme. This enzyme participates in tryptophan metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1B6B, 1IB1, 1KUV, 1KUX, 1KUY, and 1L0C.

[edit] References

IUBMB entry for 2.3.1.87
BRENDA references for 2.3.1.87 (Recommended.)
PubMed references for 2.3.1.87
PubMed Central references for 2.3.1.87
Google Scholar references for 2.3.1.87
Voisin P, Namboodiri MA, Klein DC (1984). "Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland". J. Biol. Chem. 259: 10913–8. PMID 6469990.
Fauchere JL, Boutin JA (2000). "Substrate specificity and inhibition studies of human serotonin N-acetyltransferase". J. Biol. Chem. 275: 8794–805. doi:10.1074/jbc.275.12.8794. PMID 10722724.
Khalil EM and Cole PA (1998). "A potent inhibitor of the melatonin rhythm enzyme". J. Am. Chem. Soc. 120: 6195–6196. doi:10.1021/ja981365a.