AQP5

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Aquaporin 5
Identifiers
Symbol(s) AQP5;
External IDs OMIM: 600442 MGI: 106215 HomoloGene: 20398
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 362 11830
Ensembl ENSG00000161798 ENSMUSG00000044217
Uniprot P55064 Q9WTY4
Refseq NM_001651 (mRNA)
NP_001642 (protein)		 XM_001003734 (mRNA)
XP_001003734 (protein)
Location Chr 12: 48.64 - 48.65 Mb Chr 15: 99.42 - 99.42 Mb
Pubmed search [1] [2]

Aquaporin 5, also known as AQP5, is a human gene.[1]

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.[1]

Contents

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: AQP5 aquaporin 5.

[edit] Further reading

  • Verkman AS (2003). "Role of aquaporin water channels in eye function.". Exp. Eye Res. 76 (2): 137–43. PMID 12565800. 
  • Lee MD, Bhakta KY, Raina S, et al. (1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization.". J. Biol. Chem. 271 (15): 8599–604. PMID 8621489. 
  • Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13.". Genomics 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644. 
  • Smith JK, Siddiqui AA, Modica LA, et al. (1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands.". J. Interferon Cytokine Res. 19 (8): 929–35. doi:10.1089/107999099313479. PMID 10476940. 
  • Kreda SM, Gynn MC, Fenstermacher DA, et al. (2001). "Expression and localization of epithelial aquaporins in the adult human lung.". Am. J. Respir. Cell Mol. Biol. 24 (3): 224–34. PMID 11245621. 
  • Gresz V, Kwon TH, Hurley PT, et al. (2001). "Identification and localization of aquaporin water channels in human salivary glands.". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G247–54. PMID 11408278. 
  • Nejsum LN, Kwon TH, Jensen UB, et al. (2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 511–6. doi:10.1073/pnas.012588099. PMID 11773623. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Burghardt B, Elkaer ML, Kwon TH, et al. (2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas.". Gut 52 (7): 1008–16. PMID 12801959. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Chen Z, Wang X, Gao L, et al. (2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells.". Biochem. Biophys. Res. Commun. 342 (3): 775–81. doi:10.1016/j.bbrc.2006.01.103. PMID 16500622. 
  • Sidhaye VK, Güler AD, Schweitzer KS, et al. (2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions.". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4747–52. doi:10.1073/pnas.0511211103. PMID 16537379. 
  • Pedersen PS, Braunstein TH, Jørgensen A, et al. (2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress.". Pflugers Arch. 453 (6): 777–85. doi:10.1007/s00424-006-0157-3. PMID 17043812. 
  • Skowron-zwarg M, Boland S, Caruso N, et al. (2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation.". Exp. Cell Res. 313 (12): 2695–702. doi:10.1016/j.yexcr.2007.02.035. PMID 17553491. 

[edit] External links

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Membrane transport protein: ion channels
Ca2+: Calcium channel
Na+: Sodium channel
Navα (1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.9, 7A) • Navβ (1, 2, 3, 4) • Epithelial sodium channel
K+: Potassium channel
Cl-: Chloride channel
Porin
Cations: TRP
TRPA (1) • TRPC (1, 2, 3, 4, 4AP, 5, 6, 7) • TRPM (1, 2, 3, 4, 5, 6, 7, 8) • TRPML (Mucolipin-1) • TRPP (1, 2) • TRPV (1, 2, 3, 4, 5, 6)
Other/general